| 不对称姜黄素类似物的合成及其清除自由基的研究 |
| |
| 引用本文： | 杜志云,涂增清,张焜,卢宇靖,莫容清,汤志恺.不对称姜黄素类似物的合成及其清除自由基的研究[J].化学研究与应用,2011,23(9):1126-1131. |
| |
| 作者姓名： | 杜志云 涂增清 张焜 卢宇靖 莫容清 汤志恺 |
| |
| 作者单位： | 广东工业大学轻工化工学院,广东广州,510006 |
| |
| 基金项目： | 广东省科技计划资助项目(2007A020300007-10) |
| |
| 摘 要： | 姜黄素类化合物中,非对称结构的单去甲氧基姜黄素具有一些特殊的生物活性.通过碱法合成2-单取代苯亚甲基环戊酮中间体,再用酸催化合成了10不对称的单羰基姜黄素类似物,多酚羟基的类似物可以不通过羟基保护直接合成,其中,除A1外其它9个为新化合物,并测试了所合成类似物对DPPH自由基的清除能力.结果表明类似物的酚羟基对自由基清...
|
| 关 键 词： | 姜黄素 不对称姜黄素类似物 清除自由基 DPPH |
Synthesis and free radical scavenging abilities of unsymmetrical curcumin analogues |
| |
| DU Zhi-yun,TU Zeng-qing,ZHANG Kun,LU Yu-jing,MO Rong-qing,TANG Zhi-kai.Synthesis and free radical scavenging abilities of unsymmetrical curcumin analogues[J].Chemical Research and Application,2011,23(9):1126-1131. |
| |
| Authors: | DU Zhi-yun TU Zeng-qing ZHANG Kun LU Yu-jing MO Rong-qing TANG Zhi-kai |
| |
| Institution: | DU Zhi-yun,TU Zeng-qing,ZHANG Kun,LU Yu-jing,MO Rong-qing,TANG Zhi-kai(School of Light Industry and Chemical Engineering,Technical University of Guangdong,Guangzhou 510006,China) |
| |
| Abstract: | Demethoxycurcumin of curcuminoids,with non-symmetrical structure,exhibited some special biological activities.Totally,Except A1 9 new unsymmetrical curcumin analogues were synthesized through reacting the key intermediates 2-arylidenecyclopentanones catalyzed by base with other aromatic benzaldehydes in the acidic condition,the poly phenolic analogues could easily obtained without protecting the hydroxyl groups,and their ability to scavenge DPPH free radical was evaluated.The results revealed that the pheno... |
| |
| Keywords: | curcumin unsymmetrical curcumin analogues free radical scavenging DPPH |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
