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| 头孢美唑钠与BSA及纳米银-BSA体系相互作用的研究 | |
| 引用本文： | 张怀斌,张洪芹,董秀丽,李怀祥.头孢美唑钠与BSA及纳米银-BSA体系相互作用的研究[J].化学研究与应用,2011,23(11):1428-1434. |
| 作者姓名： | 张怀斌 张洪芹 董秀丽 李怀祥 |
| 作者单位： | 1. 滨州医学院(烟台校区)化学教研室,山东烟台,264003 2. 滨州医学院(烟台校区)基础学院,山东烟台,264003 3. 山东师范大学化学化工与材料科学学院,山东济南,250014 |
| 基金项目： | 国家自然科学基金资助项目(6067101020775045); 滨州医学院科研专项资助项目(BY2009KJ30) |
| 摘 要： | 纳米银与牛血清白蛋白(BSA)均匀混合形成纳米银-BSA体系,运用荧光光谱,紫外吸收光谱,同步荧光光谱研究了注射用头孢美唑钠(Cefmetazole Sodium for Injection,CS)与BSA及纳米银-BSA体系的相互作用.头孢美唑钠对BSA具有荧光猝灭作用,其猝灭方式为静态猝灭,求出了猝灭常数,结合常数... |
| 关 键 词： | 头孢美唑钠 牛血清白蛋白 纳米银 荧光光谱 热力学参数 紫外可见光普 |
Studies on the interaction between cefmetazole sodium and bovine serum albumin or the system of nanosilver-BSA |
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| ZHANG Huai-bin,ZHANG Hong-qin,DONG Xiu-li,LI Huai-xiang.Studies on the interaction between cefmetazole sodium and bovine serum albumin or the system of nanosilver-BSA[J].Chemical Research and Application,2011,23(11):1428-1434. | |
| Authors: | ZHANG Huai-bin ZHANG Hong-qin DONG Xiu-li LI Huai-xiang |
| Institution: | ZHANG Huai-bin1,ZHANG Hong-qin2,DONG Xiu-li1,LI Huai-xiang3(1.Chemistry Staff Room,Binzhou Medical College,Yaitai 264003,China,2.Foundation Institute,3.College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University,Jinan 250014,China) |
| Abstract: | The silver nanoparticles and bovine serum albumin(BSA)mixting formed the system of nanosilver-BSA.The interaction between cefmetazole sodium for injection(CS)and bovine serum albumin(BSA)without nanosilver or with nanosilver has been investigated by the fluorescence spectrometry,ultraviolet absorption spectrometry,sychronous fluorescence spectrometry.The fluorescence of BSA was quenched by CS,and the quenching mechanism of BSA was a static quenching process.The quenching data were analyzed according to Ster... |
| Keywords: | cefmetazole sodium bovine serum albumin nanosilver fluorescence spectrum thermodynamic parameter ultraviolet spectrum |
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