| 面包酵母催化水相合成手性2-羟基-4-苯基丁酸乙酯的研究 |
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| 引用本文： | 石玉刚,方云,蒋南,夏咏梅.面包酵母催化水相合成手性2-羟基-4-苯基丁酸乙酯的研究[J].化学研究与应用,2006,18(4):426-430. |
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| 作者姓名： | 石玉刚 方云 蒋南 夏咏梅 |
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| 作者单位： | 江南大学化学与材料工程学院,江苏,无锡,214036 |
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| 摘 要： | 手性醇是合成众多手性药物的中间体1],手性2-羟基-4-苯基丁酸乙酯(HPBE)是血管紧张肽-转化酶抑制剂普利系列的关键手性中间体,已有许多相关制备方法的报道2,3]。利用微生物或酶将前手性α-氧代酯类化合物不对称还原为手性α-羟基酯类化合物是较有应用前景的方法之一4,5]。由
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| 关 键 词： | 面包酵母 不对称还原 手性 2-羟基-4-苯基丁酸乙酯 |
| 文章编号： | 1004-1656（2006）04-0426-05 |
| 收稿时间： | 2005-07-19 |
| 修稿时间： | 2005-09-10 |
Synthesis of chiral ethyl-2-Oxo-4-phenylbutyrate catalyzed by saccharomyces cerevisiae in aqueous phase |
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| SHI Yu-gang,FANG Yun,JIANG Nan,XIA Yong-mei.Synthesis of chiral ethyl-2-Oxo-4-phenylbutyrate catalyzed by saccharomyces cerevisiae in aqueous phase[J].Chemical Research and Application,2006,18(4):426-430. |
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| Authors: | SHI Yu-gang FANG Yun JIANG Nan XIA Yong-mei |
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| Institution: | School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, China |
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| Abstract: | The asymmetric reduction of ethyl-2-oxo-4-phenylbutyrate(OPBE) catalyzed by Saccharomyces cerevisiae in aqueous phase to synthesize chiral ethyl-2-hydroxy-4-phenylbutyrate(HPBE) was investigated in detail.The enantiomeric excess value(ee%) of product(S)-HPBE reached up to 80% determined by using chiral GC.The byproduct of the above reaction was characterized as 3-phenylpropanol(PPN) by means of GC-MS.The reaction process and mechanism of the byproduct PPN was also discussed. |
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| Keywords: | Saccharomyces cerevisiae asymmetric reduction chirality ethyl-2-hydroxy-4-phenylbutyrate |
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