| Ni(PPh 3)2Cl2催化2-氯嘧啶与芳基硼酸的Suzuki-Miyaura偶联反应 |
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| 引用本文： | 巩海鹏,肖雯,胡冰,高帆,张祯.Ni(PPh 3)2Cl2催化2-氯嘧啶与芳基硼酸的Suzuki-Miyaura偶联反应[J].化学研究与应用,2021(1):115-122. |
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| 作者姓名： | 巩海鹏 肖雯 胡冰 高帆 张祯 |
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| 作者单位： | 甘肃农业大学理学院 |
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| 基金项目： | 甘肃农业大学学科建设专项资金项目(GAU-XKJS-2018-121)资助。 |
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| 摘 要： | 本文在Ni(PPh 3)2Cl 2催化下顺利实现了不同取代基2-氯嘧啶与芳基硼酸的Suzuki-Miyaura偶联反应。实验表明,取代基的电子效应和空间位阻效应对2-氯嘧啶的反应活性影响较小。该反应产率良好,官能团耐受性好,为2-芳基嘧啶衍生物的合成提供了一类简单有效的方法。
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| 关 键 词： | SUZUKI偶联 2-氯嘧啶 芳基硼酸 镍催化 |
Nickel-catalyzed Suzuki-Miyaura coupling reaction of 2-chloro pyrimidines with aryl boronic acid |
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| GONG Hai-peng,XIAO Wen,HU Bing,GAO Fan,ZHANG Zhen.Nickel-catalyzed Suzuki-Miyaura coupling reaction of 2-chloro pyrimidines with aryl boronic acid[J].Chemical Research and Application,2021(1):115-122. |
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| Authors: | GONG Hai-peng XIAO Wen HU Bing GAO Fan ZHANG Zhen |
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| Institution: | (College of Science,Gansu Agricultural University,Lanzhou 730070,China) |
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| Abstract: | The Ni(PPh 3)2Cl 2 catalyzed Suzuki-Miyaura coupling reaction of various 2-chloro pyrimidines with aryl boronic acids was successfully achieved.The experimental results showed that the electronic and steric hindrance effect of substituents had little effect on the reactivity of 2-chloro pyrimidines.This reaction provided a simple and effective way for the synthesis of 2-aryl pyrimidine derivatives because of its excellent yield and functional group tolerance. |
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| Keywords: | Suzuki coupling 2-chloro pyrimidines aryl boronic acid nickel catalysis |
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