羟丙基-β-环糊精对双苯氟嗪包合作用的热力学研究 |
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引用本文: | 杨彩琴,王静,纪桂霞.羟丙基-β-环糊精对双苯氟嗪包合作用的热力学研究[J].化学研究与应用,2010,22(4). |
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作者姓名: | 杨彩琴 王静 纪桂霞 |
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作者单位: | 河北医科大学药学院,河北,石家庄,050017 |
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摘 要: | The inclusion complexes formation of dipfluzine(DF)with hydroxpropy -β-cyclodextrin(HP-β-CD)in aqueous solution was investigated by the phase-solubility method.With the increase of HP-β-CD concentration in aqueous sloutions,the solubility of DF increased linearly,which showed typical AL-type phase solubility diagram.The molar ratio of the DF-HP-β-CD complex was 1: 1.The effect of temperature on the reaction was studied through thermodynamics.The apparent stability constants of inclusion reation were determined.Thermodynamic parameters during the inclusion process were as follows: △_rH=30.58 kJ·mol~(-1),△_rS=158.8 J·mol~(-1)·K~(-1),△_rG<0.The complex process was endothermic and spontaneous.With the increase of temperature,the tendency of spontaneous reaction increased.
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关 键 词: | 双苯氟嗪 羟丙基-β-环糊精 相溶解度 稳定常数 热力学 hydroxpropy-β-cyclodextrin |
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