| 氧头孢中间体的溴代反应研究 |
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| 引用本文： | 夏小冬,袁红,罗忠枚,叶家林,曹胜华,丁小东.氧头孢中间体的溴代反应研究[J].化学研究与应用,2012,24(4):650-652. |
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| 作者姓名： | 夏小冬 袁红 罗忠枚 叶家林 曹胜华 丁小东 |
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| 作者单位： | 1. 中国医药集团总公司 四川抗菌素工业研究所,四川成都,610052
2. 四川大学分析测试中心,四川成都,610064 |
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| 摘 要： | 以6-APA(6-氨基青霉烷酸)为原料,经过苯甲酰化保护,硫的氧化,二苯甲酯保护,7位氨基异构化,开环重排,得到异丙烯基表唑啉。用NBS,溴素分别尝试进行溴代,最终得到两个溴代物异构体,并经过核磁共振氢谱对结构进行了确证。
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| 关 键 词： | 氧头孢中间体 异丙烯基表唑啉 溴代 |
Bromination research of oxacephem intermediate |
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| XIA Xiao-dong
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YUAN Hong
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LUO Zhong-mei
,
YE Jia-lin
,
CAO Sheng-hua
,
DING Xiao-dong.Bromination research of oxacephem intermediate[J].Chemical Research and Application,2012,24(4):650-652. |
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| Authors: | XIA Xiao-dong YUAN Hong LUO Zhong-mei YE Jia-lin CAO Sheng-hua DING Xiao-dong |
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| Institution: | 1.Sichuan Industrial Institute of Antibiotics,China National Pharmaceutical Group Corporation,Chengdu 610052,China;2.Analytical & Testing Center,Sichuan University,Chengdu 610064,China) |
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| Abstract: | Starting from 6-APA(6-aminopenicillanic acid),the isopropenylepioxazoline was synthesized through five main steps: protection by benzoylation,oxidation of sulfur,protection by diphenylmethyl ester,the iso-merization of 7-amino group,as well as decyclization and rearrangement.Two brominated isomers were obtained with the use of NBS and bromine,and their structures were testified by 1 H-NMR. |
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| Keywords: | oxacephem intermediate isopropenylepioxazoline bromination |
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