| 丙酮酸及其衍生物的某些特异反应研究 |
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| 引用本文： | 杨福蕊,高培培,陈河如,蔡绍晖.丙酮酸及其衍生物的某些特异反应研究[J].化学研究与应用,2012,24(5):764-768. |
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| 作者姓名： | 杨福蕊 高培培 陈河如 蔡绍晖 |
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| 作者单位： | 1. 暨南大学药学院中药及天然药物研究所,广东广州 510632;广东省中药药效物质基础及创新药物研究重点实验室,广东广州 510632
2. 暨南大学药学院药理教研室,广东广州,510632 |
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| 基金项目： | 国家自然科学基金，广东省科技计划项目 |
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| 摘 要： | 合成了3个丙酮酸的衍生物.结果发现,2'-(N-苄氧羰基甘氨酰脯氨酰胺基)丙酮酸乙酯不稳定,该化合物可以通过自催化水解；与其他脂肪酸不同,丙酮酸与N,N-二异丙基碳二亚胺(DIC)反应形成稳定的加合物,该加合物对醇以及二级胺不敏感；在酰肼的作用下,1-氯-N,N,2-三甲基丙烯胺不能将丙酮酸转化为丙酮酰氯,而是得到2-羟基丙烯酸异丁基酯.
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| 关 键 词： | 丙酮酸 自催化 酰肼还原 |
Some specific reactions of pyruvic acid and its derivatives |
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| YANG Fu-rui
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GAO Pei-pei
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CHEN He-ru
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CAI Shao-hui.Some specific reactions of pyruvic acid and its derivatives[J].Chemical Research and Application,2012,24(5):764-768. |
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| Authors: | YANG Fu-rui GAO Pei-pei CHEN He-ru CAI Shao-hui |
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| Institution: | 1.Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy,Jinan University,Guangzhou 510632,China; 2.Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Guangzhou 510632,China; 3.Department of Clinical Pharmacology,College of Pharmacy,Jinan University,Guangzhou 510632,China) |
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| Abstract: | Three new compounds derived from pyruvic acid had been synthesized.It was found that 2′-(N-carbobenoxy glycyl prolyl)amino ethyl pyruvate was not stable.The compound was able to hydrolyze via self-catalyzed mechanism.Unlike other aliphatic acid,pyruvic acid reacted with N,N-diisopropylcarbodiimide to form a stable adduct.This adduct was not sensitive to alcohol and secondary amine.Under the interaction of acyl hydrazine,1-chloro-N,N,2-trimethylpropenylamine could not turn pyruvic acid into pyruvyl chloride.Surprisingly,iso-butyl 2-hydroxyacrylate was produced under the reduction of acylhydrazine. |
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| Keywords: | pyruvic acid self catalysis acylhydrazine reduction |
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