| 手性氨基醇衍生物催化苯基锂与亚胺的不对称加成反应研究 |
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| 引用本文： | 王旭,张爱琴,陈学明,黄玲,黎星术.手性氨基醇衍生物催化苯基锂与亚胺的不对称加成反应研究[J].化学研究与应用,2012,24(7):1147-1151. |
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| 作者姓名： | 王旭 张爱琴 陈学明 黄玲 黎星术 |
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| 作者单位： | 1. 中山大学药学院,广东广州,510006
2. 深圳信立泰药业股份有限公司,广东深圳,518102 |
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| 摘 要： | 本文报道几种不同结构的手性氨基醇衍生物在亚胺与苯基锂不对称加成反应中的应用,并对配体结构与对映选择性的关系进行了初步探索,研究结果表明,在双手性配体中,具有反式(S,S)构型的配体催化效果优于顺式(S,R)。
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| 关 键 词： | 手性氨基醇配体 有机锂试剂 不对称加成 |
Ligands derived from β-amino alcohols for asymmetric addition of aryllithium reagents to imines |
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| WANG Xu
,
ZHANG Ai-qing
,
CHEN Xue-min
,
HUANG Ling
,
LI Xing-shu.Ligands derived from β-amino alcohols for asymmetric addition of aryllithium reagents to imines[J].Chemical Research and Application,2012,24(7):1147-1151. |
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| Authors: | WANG Xu ZHANG Ai-qing CHEN Xue-min HUANG Ling LI Xing-shu |
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| Institution: | 1*(1.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China; 2.Shenzhen Salubris Pharmaceuticals co.,LTD,shengzhen 518102,China) |
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| Abstract: | Asymmetric addition of phenyllithium reagent to aromatic imines catalyzed by several ligands derived from β-amino alcohols was reported.The preliminary study of the relationship between the structure of ligands and enantioselectivity indicated that the(S,S)β-amino alcohol ligand was superior to its(R,R)enantiomer in the catalytic reaction. |
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| Keywords: | ligands from β-amino alcohols aryllithium reagents asymmetric addition |
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