肉桂酸及其衍生物对活性氧H2O2清除作用

活性氧分子在生物内所引起的脂质过氧化可造成组织和细胞的损伤。因此，从天然产物中寻找抗活性氧的物质已引起国内外广泛重视。本文采用化学发光分析法，利用H2O2-CTMAB-鲁米诺发光体系，研究了中草药有效成分咖啡酸、氯原酸、连翘酯甙、阿魏酸、对．羟基香豆酸、间-羟基香豆酸、肉桂酸抗活性氧H2O2的作用。并与公认的抗活性氧物质抗坏血酸(Vc)进行了比较。

Scavenging effects of the derivants of Cinnamic acid on H2O2

Caffeic acid,chlorogenic acid and forsythiaside are active components of Chinese herbs and have diverse biological activities.As the similar compounds,they all include 3,4-dihydroxy-phenyl in their structures.In this paper,the scavenging effects of the caffeic acid,chlorogenic acid and forsythiaside on H_2O_2 were studied by means of chemiluminescence.The results show that scavenging effects of caffeic acid and ferulic acid on H_2O_2 were strong,and,chlorogenic acid,forsythiaside,p-coumaric acid and m-coumaric acid had relative weak scavenging ability,and cinnamic acid had little.The relationships of structure and reactivity indicate that the reactivity of phenolic hydroxyl could be increased if there was a heteroatom with p-tape lone pair of electrons(such as -OH,-OCH_3)in the ortho position of it,and phenolic hydroxyl which in the para position of -CHCHCOOH had relative strong reactivity.