Synthesis of a heterodinuclear ruthenium(II)–platinum(II) complex linked by l-cysteine methyl ester |
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| Authors: | Sarah J Yousouf Craig R BrodieNial J Wheate Janice R Aldrich-Wright |
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| Institution: | School of Biomedical and Health Sciences, University of Western Sydney, Campbelltown, NSW 2560, Australia |
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| Abstract: | A potential anticancer heterodinuclear ruthenium(II)–platinum(II) complex, ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their Δ- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV–Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry. |
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| Keywords: | Ruthenium(II) Platinum(II) Heterodinuclear l-Cysteine methyl ester Phenanthroline Anticancer |
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