Preparation, quality control and stability of 131I-Lanreotide |
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Authors: | Shahid Pervez A Mushtaq |
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Institution: | (1) Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan;(2) Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan |
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Abstract: | Summary Lanreotide, a synthetic octapeptide analog of a native hormone somatostatin, was labeled with 131I, the most widely used therapeutic and easily available radionuclide. Radioiodination of Lanreotide was carried out by Chloramine-T
and Iodogen methods. Chloramine-T and Iodogen were used as oxidizing agents to form an electrophilic iodine species, which
then labeled the tyrosine of Lanreotide. The maximum radiolabeling yield was ~80%. Chloramine-T was found more suitable than
the Iodogen method, because nearly 25% of the initial iodine activity was lost/adsorbed on the Iodogen coating. Thin layer
and high performance liquid chromatographies were used for monitoring the reaction of 131I with Lanreotide, the stability and purity of 131I-Lanreotide. |
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