Micelles based on gold-glycopolymer complexes as new chemotherapy drug delivery agents |
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| Authors: | Pearson Samuel Scarano Wei Stenzel Martina H |
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| Institution: | Centre for Advanced Macromolecular Design, University of New South Wales, Sydney, Australia. |
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| Abstract: | Polymeric versions of deacetylated auranofin, a gold complex with a sugar ligand, were prepared by post-modifying RAFT glycopolymers. Micellisation of a block copolymer containing pendant Au(I) units produced nanoparticles with an increased anti-proliferative effect against OVCAR-3 human ovarian carcinoma cells. |
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