A general synthesis of dirhodium metallopeptides as MDM2 ligands |
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| Authors: | Zaykov Alexander N Ball Zachary T |
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| Institution: | Department of Chemistry, Rice University, 6100 Main St., MS60, Houston, TX 77005, USA. |
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| Abstract: | A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed. |
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