Catalytic asymmetric synthesis of O-acetyl cyanohydrins from KCN,Ac2O and aldehydes |
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| Authors: | Belokon Yuri N Gutnov Andrey V Moskalenko Margarita A Yashkina Lidia V Lesovoy Denis E Ikonnikov Nicolai S Larichev Vladimir S North Michael |
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| Institution: | A.N. Nesmeyanov Institute of Organo-Element Compounds Russian Academy of Sciences 119991, Moscow, Vavilov 28, Russia. yubel@ineos.ac.ru |
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| Abstract: | A (salen)titanium catalyst has been found to induce the asymmetric addition of potassium cyanide and acetic anhydride to aldehydes, giving enantiomerically enriched cyanohydrin esters with up to 92% enantiomeric excess using just 1 mol% of the catalyst. This is the first report of the asymmetric synthesis of cyanohydrin derivatives using a cyanide source which is non-volatile and inexpensive. |
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