Dimeric Manganese-Catalyzed Hydroarylation and Hydroalkenylation of Unsaturated Amides |
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| Authors: | Dongping Wang Jie Dong Wenjing Fan Prof Dr Xiang-Ai Yuan Prof Dr Jian Han Prof Dr Jin Xie |
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| Institution: | 1. State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 China;2. School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165 China |
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| Abstract: | An unprecedented Mn(I)-catalyzed selective hydroarylation and hydroalkenylation of unsaturated amides with commercially available organic boronic acids is reported. Alkenyl boronic acids have been successfully employed for the first time in Mn(I)-catalyzed carbon–carbon bond formation. A wide array of β-alkenylated amide products can be obtained in moderate to good yields, which offers practical access to five- and six-membered lactams. This protocol has predictable regio- and chemoselectivity, excellent functional group compatibility and ease of operation in air, representing a significant step-forward towards manganese-catalyzed C−C coupling. |
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| Keywords: | alkene alkenylation arylation homogeneous catalysis manganese |
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