Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion |
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Authors: | Raoul Walther Anna K Winther Anne Sofie Fruergaard Wouter vandenAkker Lise Srensen Signe Maria Nielsen Morten T JarlstadOlesen Yitao Dai Henrik S Jeppesen Paolo Lamagni Aleksandr Savateev Sren Lykke Pedersen Camilla Kaas Frich Ccile Vigier‐Carrire Nina Lock Mandeep Singh Vipul Bansal Rikke L Meyer Alexander N Zelikin |
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Institution: | Raoul Walther,Anna K. Winther,Anne Sofie Fruergaard,Wouter van den Akker,Lise Sørensen,Signe Maria Nielsen,Morten T. Jarlstad Olesen,Yitao Dai,Henrik S. Jeppesen,Paolo Lamagni,Aleksandr Savateev,Søren Lykke Pedersen,Camilla Kaas Frich,Cécile Vigier‐Carrière,Nina Lock,Mandeep Singh,Vipul Bansal,Rikke L. Meyer,Alexander N. Zelikin |
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Abstract: | Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near‐exclusively performing redox reactions. We present an unexpected discovery of non‐proteinaceous enzymes based on metals, metal oxides, 1D/2D‐materials, and non‐metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan‐glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human metabolites and privileged prodrugs in the field of enzyme‐prodrug therapies. Lastly, nanozymes are employed for conversion of glucuronide prodrugs into marketed anti‐inflammatory and antibacterial agents, as well as “nanozyme prodrug therapy” to mediate antibacterial measures. |
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Keywords: | Enzym-Prodrug-Therapien Enzymmimetika Glucuronide Nanozyme Prodrugs |
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