Late‐Stage Peptide Diversification through Cobalt‐Catalyzed C−H Activation: Sequential Multicatalysis for Stapled Peptides |
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Authors: | Mlanie M Lorion Nikolaos Kaplaneris Jongwoo Son Rositha Kuniyil Lutz Ackermann |
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Institution: | Mélanie M. Lorion,Nikolaos Kaplaneris,Jongwoo Son,Rositha Kuniyil,Lutz Ackermann |
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Abstract: | Bioorthogonal late‐stage diversification of structurally complex peptides has enormous potential for drug discovery and molecular imaging. In recent years, transition‐metal‐catalyzed C?H activation has emerged as an increasingly viable tool for peptide modification. Despite major accomplishments, these strategies largely rely on expensive palladium catalysts. We herein report an unprecedented cobalt(III)‐catalyzed peptide C?H activation, which enables the direct C?H functionalization of structurally complex peptides, and sets the stage for a multicatalytic C?H activation/alkene metathesis/hydrogenation strategy for the assembly of novel cyclic peptides. |
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Keywords: | C-H-Aktivierung Cobalt Cyclopeptide Metathese Peptide |
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