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| 壳聚糖丝心蛋白包药微球的结构和释放性能研究 | |
| 引用本文： | 彭湘红,张俐娜,潘雪龙.壳聚糖丝心蛋白包药微球的结构和释放性能研究[J].高分子学报,2000,9(4):502-505. |
| 作者姓名： | 彭湘红 张俐娜 潘雪龙 |
| 作者单位： | 1. 华中理工大学汉口分校化工系,武汉,430012 2. 武汉大学化学系,武汉,430072 3. 昆山双鹤药业有限责任公司,江苏,215315 |
| 基金项目： | 上海中金投资集团和中科院广州纤维素化学开放实验室资助 |
| 摘 要： | 近年,高分子微球的研究与开发十分引人注目.将药物包裹于微球中,经主动和被动控制,进入预定靶器官或组织后缓慢释放出,不仅可降低其毒副作用,还可提高其生物活性利用度,壳聚糖(ＣＳ)可作牛血清白蛋白等药物缓释微球的载体1～3].丝心蛋白(ＦＢ)含18种氨基酸,具有多孔性和良好的渗透性4],也是一种理想的生物材料.壳聚糖和丝心蛋白共混可交联成半互穿聚合物网络(ＳｅｍｉＩＰＮ)结构.具有智能水凝胶的性能5].本实验室已用纤维素铜氨液分别与干酪素、海藻酸钠及魔芋共混制得共混膜,两种分子间存在由次价键力引起的很强的相互作用,使其力学性… |
| 关 键 词： | 壳聚糖 丝心蛋白 非诺洛芬钙 共混微球 缓释 |
STUDIES ON THE STRUCTURE AND CONTROLLED RELEASE OF CHITOSAN/FIBROIN MICROSPHERE INCLUSION DRUG |
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| PENG Xianghong,ZHANG Lina,PAN Xuelong.STUDIES ON THE STRUCTURE AND CONTROLLED RELEASE OF CHITOSAN/FIBROIN MICROSPHERE INCLUSION DRUG[J].Acta Polymerica Sinica,2000,9(4):502-505. | |
| Authors: | PENG Xianghong ZHANG Lina PAN Xuelong |
| Abstract: | Miscibility of the fibroin, which was soluble in CaCl\-2\|H\-2O\|C\-2H\-5OH aqueous solution, mixed with chitosan was investigated, and its microspheres were prepared. The chitosan (CS)/fibroin (FB) microsphere inclusion fenoprofen calcium (CS\|FB\|FC) was prepared, and its structure was analyzed by FTIR, X\|ray and SEM. The results indicated that blend of chitosan, fibroin and fenoprofen calcium in aqueous solution is miscible, and strong interaction caused by intermolecular hydrogen bonding exits in CS\|FB\|FC. It was indicated that approximately 77% of fenoprofen from the microsphere were released in phosphate\|buffered saline(pH=7.4) within the initial 6h, and with increasing the glutaraldehyde concentration, the release of fenoprofen decreased. |
| Keywords: | Chitosan Fibroin Fenoprofen calcium Blend microsphere Controlled release |
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