| 高分子药物研究——Ⅱ.主链含5-氟脲嘧啶聚酯的合成 |
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| 引用本文： | 卓仁禧,陈衢生,刘高伟,刘振华,王宣.高分子药物研究——Ⅱ.主链含5-氟脲嘧啶聚酯的合成[J].高分子学报,1984,0(1):11-15. |
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| 作者姓名： | 卓仁禧 陈衢生 刘高伟 刘振华 王宣 |
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| 作者单位： | 武汉大学化学系
(卓仁禧，陈衢生，刘高伟，刘振华)，武汉大学化学系(王宣) |
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| 摘 要： | 本文报道主链含5-氟脲嘧啶聚酯的合成及抗动物肿瘤初步试验。将5-氟脲嘧啶在二甲基甲酰胺中与无水碳酸钾作用,所生成的5-氟脲嘧啶钾盐随即与双氯乙酸二醇酯进行共缩聚,得到了6种主链含5-氟脲嘧啶的聚酯。同时还合成了三种新的双氯代乙酸二醇酯单体。
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| 收稿时间： | 1982-05-26 |
STUDIES ON CHEMOTHERAPEUTIC POLYMERSⅡ. SYNTHESIS OF POLYESTERS CONTAINING 5-FLUOROURACIL IN THE MAINCHAIN |
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| Zhuo Ren-xi,Chen Qu-sheng,Liu Gao-wei,Liu Zhen-hua,Wang Xuan.STUDIES ON CHEMOTHERAPEUTIC POLYMERSⅡ. SYNTHESIS OF POLYESTERS CONTAINING 5-FLUOROURACIL IN THE MAINCHAIN[J].Acta Polymerica Sinica,1984,0(1):11-15. |
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| Authors: | Zhuo Ren-xi Chen Qu-sheng Liu Gao-wei Liu Zhen-hua Wang Xuan |
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| Institution: | Department of Chemistry; Wuhan University |
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| Abstract: | By reacting dipotassium salt of 5-fluorouracil with bis-( a -chloroacetoxy) polymethy-lenes, six new polyesters containing 5-fluorouracil in the main chain were prepared. The anti-tumor activity of some of these polymers were tested on mice against Sarcoma 180. Three new bis-( a -chloroacetoxy) polymethylene monomers were also prepared and characterized. |
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