| 热敏性高分子包裹的磁性微球的合成 |
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| 引用本文： | 丁小斌,孙宗华,万国祥,江英彦.热敏性高分子包裹的磁性微球的合成[J].高分子学报,1998(5):628-631. |
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| 作者姓名： | 丁小斌 孙宗华 万国祥 江英彦 |
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| 作者单位： | 1. 中国科学院成都有机化学研究所,成都,610041
2. 中国科学院化学研究所,北京,100080 |
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| 摘 要： | 磁性高分子微球由于其在外加磁场作用下简单、快速易行的磁分离特性，其在细胞分离、固定化酶、靶向药物等领域的应用研究日益活跃，并显示出较好的应用前景［１］．有关文献报道了制备磁性微球的不同方法［２］．Ｎ 异丙基丙烯酰胺（Ｎ ｉｓｏｐｒｏｐｙｌａｃｒｙｌａ...
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| 关 键 词： | Fe_3O_4磁流体，热敏性，磁性微球，低临界溶解温度 |
SYNTHESIS OF THERMOSENSITVE MAGNETIC POLYMER MICROSPHERES |
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| DING Xiaobin,SUN Zhonghua,WAN Guoxiang,JIANG Yingyan.SYNTHESIS OF THERMOSENSITVE MAGNETIC POLYMER MICROSPHERES[J].Acta Polymerica Sinica,1998(5):628-631. |
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| Authors: | DING Xiaobin SUN Zhonghua WAN Guoxiang JIANG Yingyan |
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| Abstract: | Fe 3O 4/P(St NIPAM) thermosensitive magnetic microspheres with core/shell structure were prepared by copolymerization of styrene(St) and N isopropylacrylamide(NIPAM) in the presence of Fe 3O 4 magnetic fluid in ethanol/water medium. The content of Fe 3O 4 is about 20～100mg/g in the microspheres. The hydrodynamic diameter of Fe 3O 4/ P(St NIPAM) is depended on temperature and shrank above the lower critical solution temperature (LCST) in water. Thermosensitive magnetic microspheres with average diameter size range from 5 to 100 μm were obtained by different reaction conditions.Higher initiator concentration formed larger Fe 3O 4/P(St NIPAM) microshpheres, Ethanol played important roles in the polymerization, while the stabilizer PEG has smaller effect for the size of Fe 3O 4/P(St NIPAM) microspheres. |
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| Keywords: | Fe 3O 4 magnetic fluid Thermosensitive Magnetic microsphere LCST |
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