| 生物可降解温度敏感性水凝胶用于甲状旁腺相关肽的可控释放 |
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| 引用本文： | 李聪,张喆,贺超良,庄秀丽,陈莉,蔡青,薛妍,张宾,王世振,孟维艳,陈学思.生物可降解温度敏感性水凝胶用于甲状旁腺相关肽的可控释放[J].高分子学报,2012(7):778-783. |
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| 作者姓名： | 李聪 张喆 贺超良 庄秀丽 陈莉 蔡青 薛妍 张宾 王世振 孟维艳 陈学思 |
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| 作者单位： | 吉林大学口腔医学院;东北师范大学化学学院;中国科学院长春应用化学研究所生态环境高分子材料重点实验室 |
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| 基金项目： | 国家自然科学基金(基金号50973108,51003103和21174142);科技部国际合作与交流专项(项目号2010DFB50890);吉林省科技发展计划(项目号201101082和20110332)资助项目 |
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| 摘 要： | 通过以两端带有碳碳双键的聚己内酯为生物可降解交联剂,N-异丙基丙烯酰胺为单体,通过自由基共聚合成了生物可降解的温度敏感性水凝胶,研究了此水凝胶体系在不同温度下的溶胀率及通过对其透光率的测试研究了水凝胶体系的温度响应性.以此水凝胶体系作为载体研究了PTHrP1-34(甲状旁腺相关肽)在不同温度下的体外药物释放行为.体外模拟释放表明,此水凝胶载药体系能实现PTHrP 1-34长达13天的持续释放,基于PTHrP1-34具有能够增加成骨细胞活性和数量并能促进骨形成的作用,同时这种有益效果取决于低剂量及间歇给药的方式.
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| 关 键 词： | 温度敏感性 水凝胶 控制释放 甲状旁腺相关肽 |
BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE |
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| Cong Li,Zhe Zhang,Chao-liang He,Xiu-li Zhuang,Li Chen,Qing Cai,Yan Xue,Bin Zhang,Shi-zhen Wang,Wei-yan Meng,Xue-si Chen.BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE[J].Acta Polymerica Sinica,2012(7):778-783. |
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| Authors: | Cong Li Zhe Zhang Chao-liang He Xiu-li Zhuang Li Chen Qing Cai Yan Xue Bin Zhang Shi-zhen Wang Wei-yan Meng Xue-si Chen |
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| Institution: | 1 School of Stomatology,Jilin University,Changchun 130021)(2 Changchun Institute of Applied Chemistry,State Key Laboratory of Polymer Physics and Chemistry,Changchun 130022)(3 College of Chemistry,Northeast Normal University,Changchun 130024) |
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| Abstract: | A series of thermo-sensitive hydrogels were designed and synthesized via radical polymerization of N-isopropylacrylamide(NIPAAm) by using a biodegradable acryloyl-poly(ε-caprolactone)-2-hydroxylethyl methacrylate(AC-PCL-HEMA) as a cross-linker.The influence of temperature on the equilibrium swelling ratio and the optical transmittance of the hydrogel was studied.The in vitro release of parathyroid hormone related peptide(PTHrP) which can increase the number and viability of osteoblasts and promote bone formation,from the hydrogel was investigated.The release profiles indicated that the sustained release of PTHrP from the smart hydrogel was over 13 days,indicating that the materials have potential applications in the field of oral implantology. |
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| Keywords: | Parathyroid hormone related peptide Thermo-sensitive Hydrogel Controlled-release |
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