首页 | 本学科首页   官方微博 | 高级检索  
     检索      

γ-核酸碱基取代丙基甲基二乙氧基硅烷的合成及其聚合反应研究
引用本文:卓仁禧,刘高伟,周元忠.γ-核酸碱基取代丙基甲基二乙氧基硅烷的合成及其聚合反应研究[J].高分子学报,1987,0(4):252-257.
作者姓名:卓仁禧  刘高伟  周元忠
作者单位:武汉大学化学系 (卓仁禧,刘高伟),武汉大学化学系(周元忠)
摘    要:本文以Υ-溴丙基甲基二乙氧基硅烷分别与尿嘧啶、胸腺嘧啶、腺嘌呤和5-氟尿嘧啶进行烷基化反应,制得了四种含有核酸碱基或5-氟尿嘧啶的新型有机硅单体。通过它们的缩聚反应,合成了六种侧基含核酸碱基或5-氟尿嘧啶的聚硅氧烷。

关 键 词:核酸碱基  5-氟尿嘧啶  硅烷  聚硅氧烷
收稿时间:1985-02-18

STUDIES ON THE SYNTHESIS AND POLYMERIZATION OF y-(NUCLEIC ACID BASE) SUBSTITUTED PROPYLMETHYLDIETHOXYSILANES
ZHUO Ren-xi,LIU Gao-wei,ZHOU Yuan-zhong.STUDIES ON THE SYNTHESIS AND POLYMERIZATION OF y-(NUCLEIC ACID BASE) SUBSTITUTED PROPYLMETHYLDIETHOXYSILANES[J].Acta Polymerica Sinica,1987,0(4):252-257.
Authors:ZHUO Ren-xi  LIU Gao-wei  ZHOU Yuan-zhong
Institution:Departmtnt of Chemistry; Wuhan University; Wuhan
Abstract:A new type of nucleic acid analogs with polysiloxane backbones is reported in this paper. Four new organosilicon monomers containing nucleic acid bases or 5-fluorouracil, i.e., γ-(N1-uracilyl) propylmethyldiethoxysilane (1), γ-(N1-thyminyl) propylmethyldiethoxysilane (2),γy-(N9-adenyl) propylmethyldiethoxysilane (4) anr-(N15-fluorouracilyl) propylmethyldiethoxysilane (3), were prepared by the alkylation of γ-bromopropylmethyldiethoxysilane with uracil, thymine, adenine and 5-fluorouracil, respectively. The polymerization of these monomers, including the copolymerization of (11 with diacetoxydimethylsilane (5), or 1,3-bis (acetoxy-1,1,3,3-tetramethyldisiloxane (6), were carried out under different conditions. Thus, a variety of ho-mopolymers and copolymers were obtained with polysiloxane structure as the main chain and nucleic acid base as the pendant group. The monomers and polymers were structurally identified by 1H-NMR, IR, UV and elemental analysis. The η] and Mn of the polymers were also determined.
Keywords:Nucleic Acid Base  5-Fluorouracil  Silane  Polysiloxane
本文献已被 CNKI 等数据库收录!
点击此处可从《高分子学报》浏览原始摘要信息
点击此处可从《高分子学报》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号