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聚丙交酯/聚乙二醇多嵌段共聚物的合成及其性能
引用本文:陈文娜,杨建,王身国,贝建中.聚丙交酯/聚乙二醇多嵌段共聚物的合成及其性能[J].高分子学报,2002(5):695-698.
作者姓名:陈文娜  杨建  王身国  贝建中
作者单位:中国科学院化学研究所分子科学研究中心,北京,100080
基金项目:国家重点基础发展规划资助项目 (973计划G19990 5 43 0 5和G19990 5 43 0 6)
摘    要:聚丙交酯 (PLLA)由于具有良好的生物降解性和生物相容性 ,在医学领域已经得到了广泛的临床应用 ,近来又被制备成细胞支架大量应用于组织工程中1,2 ] ,但由于其疏水性而造成细胞亲和性不好 .聚乙二醇 (PEG)具有良好的亲水性 ,良好的生物相容性 ,但是PEG是非降解性的 ,只有低分子量的PEG可以被吞噬细胞所吞噬或透过肾滤膜而排出体外 ,因此 ,低分子量的PEG常被用来与丙交酯 (L LA)共聚以改善PLLA支架的亲水性 .聚丙交酯 聚乙二醇共聚物 (PLE)的三嵌段及两嵌段共聚物的合成及其性能的研究已被广泛报道3~ 5] .研究…

关 键 词:聚丙交酯  聚乙二醇  多嵌段共聚物  细胞培养
修稿时间:2002年1月29日

SYNTHESIS AND PROPERTIES OF POLY(L-LACTIDE)-POLY(ETHYLENE GLYCOL) MULTIBLOCK COPOLYMERS
CHEN Wenna,YANG Jian,WANG Shenguo,BEI Jianzhong.SYNTHESIS AND PROPERTIES OF POLY(L-LACTIDE)-POLY(ETHYLENE GLYCOL) MULTIBLOCK COPOLYMERS[J].Acta Polymerica Sinica,2002(5):695-698.
Authors:CHEN Wenna  YANG Jian  WANG Shenguo  BEI Jianzhong
Abstract:A series of multiblock copolymers of PLLA\|PEG(PLE) with high molecular weight were synthesized by coupling PLLA\|PEG\|PLLA triblock copolymers with succinic anhydride in the presence of ( N,N\| dimethylamino) pyridine(DMAP) and dicyclohexylcarbodimide (DCC).The results of the viscometry measurement,GPC and 1H\|NMR,elucidated that multiblock PLE copolymers with high content of short PEG segments( M n=2000) had been successfully obtained.The crystallinity of the copolymers was investigated by X\|ray diffraction.Mechanical testing showed that multiblock copolymers had relatively high tensile strength and large elongation.In a word,the measurements showed that the multiblock PLE copolymers had high content of short PEG segments( M n=2000),high molecular weight( M w~100,000),excellent hydrophilicity and mechanical properties.The results of cells cultured on the multiblock PLE copolymer indicated that it might be suitable to be utilized as cell scaffold for tissue engineering.
Keywords:Poly(  L  \|lactide)  Poly(ethylene glycol)  Multiblock copolymer  Cell scaffold  
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