含5-氟脲嘧啶的聚硅氧烷的合成

5-氟脲嘧啶与α、ω双二乙胺基聚二取代基硅氧烷反应 可得含5-氟脲嘧啶的缩聚物。并以红外、核磁对缩聚物进行了研究。在室温将所得缩聚物在不同pH介质中,进行水解,以266.5nm处紫外吸收光度,定量测定所释放出来5-氟脲嘧啶。当缩聚物n值增大时,水解速度减慢,1、3结构则比2、4结构缩聚物为快。

SYNTHESIS OF POLYSILOXANES CONTAINING 5-FLUOROURACIL

The polysiloxanes containing 5-fluorouracil were prepared by reacting diethylaminopoly-disubstituted siloxanes with 5-fluorouracil. The obtained polymers were structural characterized by IR and H-NMR spectra. The products were hydrolyzed in acidic, alkaline and neutral medium at room temperature respectively. The amount of 5-fluorouracil released was quantitated by measuring its UV absorbance at 266.5 nm. However in the case of polymers containing dimethylsiloxy ((CH3)2SiO-) moiety, their stabilities toward hydrolysis are inc reased as the value n increases. Polymers with Si-N- linkage (type A) hydrolyze more rapidly in acidic medium but slowly in alkaline medium than the polymers with Si-O-linkage (type B).