Bioactive principles,anti-diabetic,and anti-ulcer activities of Ducrosia anethifolia Boiss leaves from the Hail region,Saudi Arabia |
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| Institution: | 1. Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail, Kingdom of Saudi Arabia;2. Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia;3. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, Kingdom of Saudi Arabia;4. College of Pharmacy, University of Hail, Kingdom of Saudi Arabia;5. Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, Giza, Egypt;6. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt;7. Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail, Kingdom of Saudi Arabia;8. Department of Pharmaceutics, School of Pharmacy, College of Health Sciences and Medicine, Wolaita Sodo University, Ethiopia;9. Department of Biochemistry, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia;10. Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt;11. Medical Research Center, Jazan University, Jazan, Kingdom of Saudi Arabia;12. Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Kingdom of Saudi Arabia |
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| Abstract: | This work aimed to identify the bioactive constituents of Ducrosia anethifolia Boiss eaves through cold methanolic extract. The GC–MS study of cold methanolic extract showed the presence of various pharmaceutically important bioactive compounds with unique peaks at specified retention time. The significant compounds are α-linoleic acid, α-sitosterol, n-hexadecanoic acid, palmitic acid β-monoglyceride, 2-methoxy-4-vinylphenol and benzoic acid, methyl ester. The FT-IR study showed them fingerprint region at 3326.80, 2943.53, 2831.74, 1450, 1110.67 and 1020.80 cm?1. The FT-IR study suggested the presence of glycosides, flavonoids, tannins, steroids, saponins, fatty acids and squalene. Oral administration of Ducrosia anethifolia Boiss leaves powder (DLP) (100 mg/kg body weight) was successfully reduced the blood sugar level after 14 d treatment in STZ (50 mg/kg bodyweight) induced diabetic rats significantly from 327.93 ± 24.5 to 171 0.03 ± 3.78 mg/dL. Furthermore, DLP (400 mg/kg body weight) was showed 74 ± 1.9 % inhibition of ulcer. The results of this study showed that DLP has both anti-diabetic and anti-ulcer characteristics when tested in vivo. |
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| Keywords: | Anti diabetic Anti-ulcer Apiaceae Bioactive constituents Leaves |
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