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| 1,3-偶极环加成合成双-4,5-二氢-1,2,4-噁二唑啉衍生物 | |
| 引用本文： | 胡君,解正峰,惠永海,貊雪霞,孙翔,刘方明.1,3-偶极环加成合成双-4,5-二氢-1,2,4-噁二唑啉衍生物[J].有机化学,2007,27(9):1162-1166. |
| 作者姓名： | 胡君 解正峰 惠永海 貊雪霞 孙翔 刘方明 |
| 作者单位： | 1. 新疆大学化学化工学院,乌鲁木齐,830046 2. 中国石油塔里木油田塔石化分公司,库尔勒,841000 3. 新疆大学化学化工学院,乌鲁木齐,830046;杭州师范学院,杭州,310012;杭州师范学院有机硅化学及材料技术教育部重点实验,杭州,310012 |
| 基金项目： | 国家自然科学基金（No.20562011）和新疆大学青年启动基金资助项目. 感谢国家新药筛选中心在样品活性测试上提供的帮助. |
| 摘 要： | 用2-苯基-1,2,3-三唑基-4-甲醛(1)或喹喔啉基-2-甲醛(2)与乙二胺缩合成双席夫碱3或4, 然后与α-氯代肟在三乙胺条件下发生1,3-偶极环加成得到双-4,5-二氢-1,2,4-噁二唑啉衍生物6a～6f或7a～7f. 目标化合物的结构经元素分析, IR, 1H NMR和MS确认. |
| 关 键 词： | 喹喔啉-2-甲醛 2-苯基-1 2 3-三唑基-4-甲醛 双席夫碱 1 3-偶极环加成 双-4 5-二氢-1 2 4-噁二唑啉衍生物 |
| 收稿时间： | 2006-7-7 |
| 修稿时间： | 2006-07-072006-10-12 |
Synthesis of Bis-4,5-dihydro-1,2,4-oxadiazolineDerivatives by 1,3-Diplor Cycloaddition |
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| HU,Jun,XIE,Zheng-Feng,HUI,Yong-Hai,MO,Xue-Xia,SUN,Xiang,LIU,Fang-Ming.Synthesis of Bis-4,5-dihydro-1,2,4-oxadiazolineDerivatives by 1,3-Diplor Cycloaddition[J].Chinese Journal of Organic Chemistry,2007,27(9):1162-1166. | |
| Authors: | HU Jun XIE Zheng-Feng HUI Yong-Hai MO Xue-Xia SUN Xiang LIU Fang-Ming |
| Institution: | 1. College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046;2. Hangzhou Teachers College, Hangzhou 310012;3. Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Teachers College, Han gzhou 310012;4.Petrochina Tarim Oilfield Petrochemical Company, Korla 841000 |
| Abstract: | Condensation of ethylenediamine with 2-phenyl-1,2,3-triazole-4-carboxaldehyde (1) or quinoxa-line-2-carboxaldehyde (2) gave bis-Schiff base 3 or 4, which then reacted with α-chloro-oximes to afford bis- bis-4,5-dihydro-1,2,4-oxadiazoline derivatives 6a～6f or 7a～7f by 1,3-dipolar cycloaddition. The structures of new compounds were confirmed by elemental analysis, IR, 1H NMR and MS spectra. |
| Keywords: | qinoxaline-2-carboxaldehyhyde 2-phenyl-1 2 3-triazole-4-carboxaldehyde bis-Schiff base 1 3-dipolar cycloaddition bis-4 5-dihydro-1 2 4-oxadiazoline derivative |
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