| 柔荑软珊瑚Nephthea sp.中两种具有细胞毒活性的甾醇化合物 |
| |
| 引用本文： | 徐石海,廖小建,林慧.柔荑软珊瑚Nephthea sp.中两种具有细胞毒活性的甾醇化合物[J].有机化学,2008,28(5):861-864. |
| |
| 作者姓名： | 徐石海 廖小建 林慧 |
| |
| 作者单位： | 暨南大学化学系,广州,510632 |
| |
| 基金项目： | 国家高技术研究发展计划(863计划)，国家自然科学基金，广东省科技计划，广州市计划基金 |
| |
| 摘 要： | 采用抗肿瘤活性追踪法对采自中国南海西沙群岛永兴岛柔荑软珊瑚Nephthea sp.中抗肿瘤活性成分进行研究, 报道了两种具有细胞毒活性的甾醇化合物, 经过MS, IR, 1H NMR, 13C NMR (DEPT), HSQC 和HMBC等光谱技术鉴定为: 24-甲基胆甾-5-烯-3β,8β-二醇(1)和24-亚甲基胆甾-4-烯-3β,6β-二醇(2), 化合物1为新化合物, 利用X-ray单晶衍射技术验证化合物2的立体结构. 化合物1对肝癌细胞(BEL-7402), 小鼠白血瘤细胞(P388)和人结肠癌细胞(LOVO)作用的IC50值分别为18.0, 25.5和20.6 μg/mL; 化合物2对肿瘤细胞P388和人乳腺癌细胞(MCF)作用的IC50值分别为1.0和2.5 μg/mL.
|
| 关 键 词： | 软珊瑚 Nephthea sp 甾醇 抗肿瘤活性 |
| 收稿时间： | 2007-8-7 |
| 修稿时间： | 2007-10-6 |
Two Cytotoxic Sterols from the Soft Coral Nephthea sp. |
| |
| XU,Shi-Hai,LIAO,Xiao-Jian,LIN,Hui.Two Cytotoxic Sterols from the Soft Coral Nephthea sp.[J].Chinese Journal of Organic Chemistry,2008,28(5):861-864. |
| |
| Authors: | XU Shi-Hai LIAO Xiao-Jian LIN Hui |
| |
| Institution: | (Department of Chemistry, Jinan University, Guangzhou 510632) |
| |
| Abstract: | Two cytotoxic sterols have been isolated from Nephthea sp. collected from Xisha islands of the South China Sea by bioassay-guided isolation. Their structures were established as 24-methylcholestan-5- ene-3β,8β-diol (1) and 24-methylenecholestan-4-ene-3β,6β-diol (2) by MS, IR, 1H NMR, 13C NMR (DEPT), HSQC and HMBC analysis. Sterol 1 is a previously unknown compound and the stereochemistry of sterol 2 has been validated by X-ray diffraction analysis for the first time. Sterol 1 exhibited cytotoxicity against BEL-7402, P388 and LOVO cells (IC50 18.0, 25.5 and 20.6 μg/mL, respectively). Sterol 2 also showed significant cytotoxicity against P388 and MCF cells (IC50 1.0 and 2.5 μg/mL, respectively). |
| |
| Keywords: | Nephthea sp |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
| 点击此处可从《有机化学》下载免费的PDF全文 |
|
