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| C(2)-酰胺基-4-芳基-1,5-苯并硫氮杂的合成及抑菌活性的研究 | |
| 引用本文： | 李文红,张玲芬,刘薇,杜星琼,李媛.C(2)-酰胺基-4-芳基-1,5-苯并硫氮杂的合成及抑菌活性的研究[J].有机化学,2011,31(8). |
| 作者姓名： | 李文红 张玲芬 刘薇 杜星琼 李媛 |
| 作者单位： | 1. 河北师范大学化学与材料科学学院 石家庄050016;河北工业职业技术学院环境与化学工程系 石家庄050091 2. 河北师范大学化学与材料科学学院 石家庄050016 3. 河北师范大学生命科学学院 石家庄050016 |
| 基金项目： | 国家自然科学基金(No.20972040); 河北省自然科学基金(No.B2009000255)资助项目 |
| 摘 要： | 设计合成了三类C(2)酰胺基取代的1,5-苯并硫氮杂衍生物:2-酰胺基(N-芳基)-4-芳基-1,5-苯并硫氮杂、2-酰胺基(N-烷基)-4-芳基-1,5-苯并硫氮杂和2-酰胺基(N,N-二烷基)-4-芳基-1,5-苯并硫氮杂,其结构用元素分析,IR,MS及1H NMR确证.测定了目标化合物的抑真菌活性,结果表明部分化合物对新生隐球菌具有中等强度的抑真菌活性.还研究了2-酰胺基-4-芳基-1,5-苯并硫氮杂的合成反应条件. |
| 关 键 词： | 1 5-苯并硫氮杂 酰胺 抑菌活性 |
Synthesis and Antifungal Activity of 2-Carboxamide-4-aryl-1,5-benzothiazepines |
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| Li Wenhong,Zhang Lingfen,Liu Wei,Du Xingqiong,Li Yuan.Synthesis and Antifungal Activity of 2-Carboxamide-4-aryl-1,5-benzothiazepines[J].Chinese Journal of Organic Chemistry,2011,31(8). | |
| Authors: | Li Wenhong Zhang Lingfen Liu Wei Du Xingqiong Li Yuan |
| Institution: | Li,Wenhonga,c Zhang,Lingfena Liu,Weib Du,Xingqiongb Li,Yuan*,a(a College of Chemistry & Material Science,Hebei Normal University,Shijiazhuang 050016)(b College of Life Sciences,Shijiazhuang 050016)(c Environment and Chemical Engineering,Hebei College of Industry and Technology,Shijiazhuang 050091) |
| Abstract: | Three kinds of 2-carboxamide-1,5-benzothiazepines including 2-carboxamide(N-aryl)-4-aryl,2-carboxamide-(N-alkyl)-4-aryl and 2-carboxamide-(N,N-alkyl)-4-aryl-1,5-benzothiazepines were designed and synthesized,and their structures were characterized by elemental analysis,IR,1H NMR,and MS techniques.Their antifungal activities against some fungi were evaluated,and the results indicated that some of them showed moderate fungicidal activities in vitro against C.neoformans.The synthesis conditions of the title co... |
| Keywords: | 1 5-benzothiazepine carboxamide antifungal activity |
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