| 水溶性氧杂酰胺类化合物的合成及表征 |
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| 引用本文： | 张平,王海荣,王建晨,陈靖.水溶性氧杂酰胺类化合物的合成及表征[J].有机化学,2008,28(2):335-338. |
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| 作者姓名： | 张平 王海荣 王建晨 陈靖 |
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| 作者单位： | 清华大学核能与新能源技术研究院,北京,102201 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 以二甘醇为原料, 经氧化得到的二甘酸, 通过氯代或缩合反应得到中间体酰氯和酸酐, 二烷基胺在吡啶催化下与酰氯或酸酐发生胺解反应, 合成出系列水溶性氧杂单酰胺及氧杂双酰胺, 包括N,N-二烷基-3-氧杂-戊酰胺酸系列和N,N,N'N'-四烷基-3-氧杂-戊二酰胺系列(烷基包括甲基、乙基和丙基). 用IR和1H NMR对合成的目标产物进行了表征.
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| 关 键 词： | 水溶性氧杂单酰胺 氧杂双酰胺 合成 表征 |
| 收稿时间： | 2006-05-23 |
| 修稿时间： | 2007-09-05 |
Synthesis and Characterization of Water-Soluble Oxa-amide Compounds |
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| ZHANG Ping,WANG Hai-Rong,WANG Jian-Chen,CHEN Jing.Synthesis and Characterization of Water-Soluble Oxa-amide Compounds[J].Chinese Journal of Organic Chemistry,2008,28(2):335-338. |
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| Authors: | ZHANG Ping WANG Hai-Rong WANG Jian-Chen CHEN Jing |
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| Institution: | (Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 102201) |
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| Abstract: | Diglycolic anhydride or diglycolic acyl chloride was prepared by the oxidation of diethylene glycol followed by dehydration or chloro-substitution. By reaction between diglycolic anhydride or diglycolic acyl chloride and dialkyl amine in the presence of pyridine as a catalyst, a series of novel water-soluble oxa-amide compounds, including N,N'-dialkyl-3-oxaglutaramic acid and N,N,N',N'-tetraalkyl-3-oxaglutar- amide (alkyl＝methyl, ethyl and propyl) were synthesized and identified with 1H NMR and IR spectra. |
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| Keywords: | oxa-monoamide oxa-diamide synthesis characterization |
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