| 碱性季铵盐“一锅法”催化合成四氢苯并[b]吡喃的水相反应研究 |
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| 引用本文： | 赵丽琴,李毅群,陈路,周波.碱性季铵盐“一锅法”催化合成四氢苯并[b]吡喃的水相反应研究[J].有机化学,2010,30(1):124-127. |
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| 作者姓名： | 赵丽琴 李毅群 陈路 周波 |
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| 作者单位： | 暨南大学化学系,广州,510632 |
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| 基金项目： | 国家级.国家自然科学基金 |
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| 摘 要： | 报道了以2-二甲氨乙基苄基二甲基氯化铵为催化剂,在水相介质中"一锅法"催化芳醛、丙二腈和5,5-二甲基-1,3-环己二酮合成2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并b]吡喃的方法.该法具有产率高、反应时间短、操作简便、对环境友好、催化剂可重复使用等优点.
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| 关 键 词： | 四氢苯并[b]吡喃 碱性季铵盐 2-二甲基氨乙基苄基二甲基氯化铵 催化 水相 |
| 收稿时间： | 2009-05-31 |
| 修稿时间： | 2009-07-15 |
One-Pot Synthesis of Tetrahydrobenzo [b]pyran Catalyzed by Basic Quaternary Ammonium Salt in Aqueous Medium |
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| Zhao Liqin,Li Yiqun,Chen Lu,Zhou Bo.One-Pot Synthesis of Tetrahydrobenzo [b]pyran Catalyzed by Basic Quaternary Ammonium Salt in Aqueous Medium[J].Chinese Journal of Organic Chemistry,2010,30(1):124-127. |
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| Authors: | Zhao Liqin Li Yiqun Chen Lu Zhou Bo |
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| Institution: | (Department of Chemistry，Jinan University，Guangzhou 510632) |
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| Abstract: | A synthesis of 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzob]-pyrans from aromatic aldehyde,malononitrile and 5,5-dimethyl-1,3-dioxocyclohexane using(2-dimethy-laminoethyl)(benzyl)dimethylammonium chloride(PhCH_2Me_2N~+CH_2CH_2NMe_2]Cl~-)as catalyst(5 mol%)was described which provided several advantages such as excellent yield,short reaction time,simple experimental and work-up procedure,reusability of catalyst and benignity to environment. |
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| Keywords: | tetrahydrobenzo[b]pyran basic quaternary ammonium salt (2-dimethylaminoethyl)(benzyl)- dimethylammonium chloride catalysis aqueous medium |
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