| 中国南海海绵Cinachyrella australiensis中(3E)-胆甾-4-烯-3,6-二酮-3-肟的结构鉴定 |
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| 引用本文： | 肖定军,彭学东,邓松之,马伟杰,吴厚铭.中国南海海绵Cinachyrella australiensis中(3E)-胆甾-4-烯-3,6-二酮-3-肟的结构鉴定[J].有机化学,2005,25(12):1606-1609. |
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| 作者姓名： | 肖定军 彭学东 邓松之 马伟杰 吴厚铭 |
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| 作者单位： | 1. 中国科学院广州化学研究所,广州,510650
2. 中国科学院上海有机化学研究所生命有机化学国家重点实验室,上海,200032 |
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| 基金项目： | 中国科学院资助项目，国家重点实验室基金 |
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| 摘 要： | 从南中国海海绵Cinachyrella australiensis的乙酸乙酯萃取部分分离出一个结构特别的甾体化合物, 应用UV, IR, MS, 1H NMR, 13C NMR, DQCOSY, NOESY, TOCSY, HMQC和HMBC等光谱分析技术, 确定它为(3E)-胆甾-4-烯-3,6-二酮-3-肟(1). 化合物1为新天然甾体化合物, 通过生理活性实验表明其对乙肝病毒Hep G2细胞有较强的细胞毒活性. 本文对其波谱数据作了详细报道.
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| 关 键 词： | 海绵 活性成分 结构鉴定 甾体 |
| 收稿时间： | 2005-1-20 |
| 修稿时间： | 2005年1月20日 |
Structure Elucidation of (3E)-Cholest-4-en-3,6-dione-3-oxime in Marine Sponge Cinachyrella australiensis from the South China Sea |
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| XIAO,Ding-Jun,PENG,Xue-Dong,DENG,Song-Zhi,MA,Wei-Jie,WU,Hou-Ming.Structure Elucidation of (3E)-Cholest-4-en-3,6-dione-3-oxime in Marine Sponge Cinachyrella australiensis from the South China Sea[J].Chinese Journal of Organic Chemistry,2005,25(12):1606-1609. |
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| Authors: | XIAO Ding-Jun PENG Xue-Dong DENG Song-Zhi MA Wei-Jie WU Hou-Ming |
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| Institution: | ( Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650)( State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai In-stitute of Organic Chemistry,Chinese Academy of Sciences, Shanghai 200032) |
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| Abstract: | A new steroid was isolated from the ethyl acetate extract fraction of marine sponge Cinachyrella australiensis collected from the South China Sea. Its structure was determined by IR, 1H NMR, 13C NMR, MS, DQCOSY, NOESY, TOCSY, HMQC and HMBC as (3E)-cholest-4-en-3,6-dione-3-oxime (1). Bioas- say showed that compound 1 was cytotoxic against Hep G2. The spectral data were reported in details in this paper. |
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| Keywords: | sponge active constituent structure elucidation steroid |
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