| 含1H-吡啶和噻（二）唑的新型双杂环化合物的合成及其生物活性 |
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| 引用本文： | 胡利明,李学恕,陈致远,刘钊杰.含1H-吡啶和噻（二）唑的新型双杂环化合物的合成及其生物活性[J].有机化学,2003,23(10):1131-1134. |
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| 作者姓名： | 胡利明 李学恕 陈致远 刘钊杰 |
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| 作者单位： | 1. 华中师范大学有机合成研究所,武汉,430079;厦门大学化学系,厦门,361005
2. 华中师范大学有机合成研究所,武汉,430079 |
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| 基金项目： | 科技部国家“九五”重点科技攻关 (No .97 563 0 2 0 5)资助项目 |
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| 摘 要： | 以苯肼、乙酰乙酸乙酯和氨基杂环为原料，合成了两类含双杂环的新型吡唑甲 酰胺衍生物，其结构经元素分析、~1H NMR，MS及IR确证。初步的生物活性测试结 果表明：部分化合物对水稻纹枯病菌、小麦赤霉病菌和苹果轮纹病菌具有良好的抑 制效果。
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| 关 键 词： | 吡唑 P 酰胺 P 苯并噻唑 噻二唑 杀菌剂 苯肼 乙酰乙酸 P |
| 修稿时间： | 2002年12月20 |
Synthesis and Biological Activity of Novel Bis-heterocyclic Compounds Containing 1H-Pyrazole and Thiazole |
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| HU,Li-Ming a,b LI,Xue-Shu a CHEN,Zhi-Yuan a LIU,Zhao-Jie,a.Synthesis and Biological Activity of Novel Bis-heterocyclic Compounds Containing 1H-Pyrazole and Thiazole[J].Chinese Journal of Organic Chemistry,2003,23(10):1131-1134. |
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| Authors: | HU Li-Ming a b LI Xue-Shu a CHEN Zhi-Yuan a LIU Zhao-Jie a |
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| Institution: | Institute of Organic Synthesis, Central China Normal University |
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| Abstract: | In order to search for novel fungicides with high activity and low toxicity, a series of bis-heterocyclic compounds containing 1H-pyrazole and thiazole were designed and synthesized from phenyl hydrazine, ethyl acetoacetate and aromatic aminoheterolcycles. The structures of all new compounds were confirmed by elemental analysis, 1H NMR, IR and MS spectra. Preliminary bioassays indicated that some compounds showed fungicidal activity against Pellicularia sasakii, Gibberella zeave and Physalospora piricola. |
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| Keywords: | 1H-pyrazole-4-carboxamide benzothiazole 1 3 4-thiadiazole fungicidal activity synthesis |
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