| 2-苯甲酰基-N-芳基氨基脲的合成及抑菌活性 |
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| 引用本文： | 郭佃顺.2-苯甲酰基-N-芳基氨基脲的合成及抑菌活性[J].有机化学,2004,24(9):1118-1121. |
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| 作者姓名： | 郭佃顺 |
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| 作者单位： | 山东师范大学化学系,济南,250014 |
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| 摘 要： | 以N-取代三氯乙酰胺在碱催化下与苯甲酰肼反应,合成了8种2-苯甲酰基-N-芳基氨基脲3a～3h,其结构经元素分析、IR和1H NMR所表征;初步生物活性测定表明,部分化合物对大肠杆菌、枯草杆菌和金黄色葡萄球菌具有一定的抑菌活性.
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| 关 键 词： | 取代氨基脲 三氯乙酰胺 合成 表征 抑菌活性 |
| 修稿时间： | 2003年11月10 |
Synthesis and Antibacterial Activities of 2-Benzoyl- N- aryl Hydrazinecarboxamides |
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| GUO,Dian-Shun.Synthesis and Antibacterial Activities of 2-Benzoyl- N- aryl Hydrazinecarboxamides[J].Chinese Journal of Organic Chemistry,2004,24(9):1118-1121. |
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| Authors: | GUO Dian-Shun |
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| Abstract: | Eight 2-benzoyl-N-arylhydrazinecarboxamides (PhCONHNHCONHAr) (Ar=2-ClC 6H 4, 3-ClC 6H 4, 4-ClC 6H 4, 3,4-Cl 2C 6H 3, 2-MeC 6H 4, 3-MeC 6H 4, 4-MeC 6H 4, 2,4-Me 2C 6H 3) have been synthesized via the reaction of N-substituted trichloroacetamides with benzoylhydrazine mediated by NaOH and characterized by elemental analyses, 1H NMR and IR spectra. The biological test shows that some compounds have displayed significant antibacterial activities against Escherichia coli, Staphylococcus aureus and Bacillus subtilis. |
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| Keywords: | substituted hydrazinecarboxamide trichloroacetamide synthesis characterization antibacterial activity |
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