| 2-氰基-2,3,3-三甲基-5-硫代-吡咯烷的合成新法 |
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| 引用本文： | 胡炳成,吕春绪,蔡超君.2-氰基-2,3,3-三甲基-5-硫代-吡咯烷的合成新法[J].有机化学,2006,26(2):219-222. |
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| 作者姓名： | 胡炳成 吕春绪 蔡超君 |
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| 作者单位： | 南京理工大学化工学院,南京,210094 |
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| 摘 要： | 以3,3-二甲基-4-戊烯酸甲酯为原料, 经过6步反应合成了目标产物2-氰基-2,3,3-三甲基-5-硫酮-吡咯烷, 反应的总收率约为37%, 其中关键步骤为分子内环化和碘化氢消除反应. 通过元素分析, 1H NMR, IR和MS对所合成化合物的结构进行了表征.
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| 关 键 词： | 氰基三甲基硫酮吡咯烷 二甲基戊烯酸甲酯 环化反应 消除反应 |
| 收稿时间： | 04 4 2005 12:00AM |
| 修稿时间： | 07 4 2005 12:00AM |
A Novel Method for Synthesis of 2-Cyano-2,3,3-trimethyl-5- thi-oxopyrrolidine |
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| HU, Bing-Cheng,L, Chun-Xu,CAI, Chao-Jun.A Novel Method for Synthesis of 2-Cyano-2,3,3-trimethyl-5- thi-oxopyrrolidine[J].Chinese Journal of Organic Chemistry,2006,26(2):219-222. |
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| Authors: | HU Bing-Cheng L Chun-Xu CAI Chao-Jun |
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| Institution: | (School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094) |
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| Abstract: | 2-Cyano-2,3,3-trimethyl-5-thioxopyrrolidine was efficiently synthesized in a total yield of 37% from methyl 3,3-dimethyl-4-pentenate via six steps, including an intramolecular cyclization and an elimina- tion of hydrogen iodide as key steps. All compounds were characterized by elemental analysis, 1H NMR, IR and MS spectra. |
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| Keywords: | cyanotrimethyl thioxopyrrolidine methyl dimethylpentenate cyclization elimination |
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