| 以2-氨基-2'-羟基-1,1'-联萘为骨架的有机小分子催化的直接羟醛缩合反应的研究 |
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| 引用本文： | 蒋毅,张小霞,王超,张国林,李伯刚.以2-氨基-2'-羟基-1,1'-联萘为骨架的有机小分子催化的直接羟醛缩合反应的研究[J].有机化学,2008,28(2):288-292. |
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| 作者姓名： | 蒋毅 张小霞 王超 张国林 李伯刚 |
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| 作者单位： | [1]中国科学院成都有机化学研究所,成都610041 [2]中国科学院成都生物研究所,成都610041 [3]中国科学院研究生院,北京100039 |
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| 摘 要： | 研究了2-氨基-2'-羟基-1,1'-联萘衍生的有机小分子催化剂催化的直接羟醛缩合反应. 以丙酮为反应物时最好, 得到了99%的收率. 以环酮为底物时, 最高得到99∶1的非对映选择性, 89%的对映选择性.
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| 关 键 词： | 2-氨基-2'-羟基-1 1'-联萘 有机小分子催化剂 直接羟醛缩合 |
| 收稿时间： | 2007-01-17 |
| 修稿时间： | 2007-08-13 |
Direct Aldol Reactions Catalyzed by Organocatalyst Derived from 2-Amino-2'-hydroxy-1,1'-binaphthyl |
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| JIANG, Yi ZHANG, Xiao-Xia WANG, Chao ZHANG, Guo-Lin LI, Bo-Gang.Direct Aldol Reactions Catalyzed by Organocatalyst Derived from 2-Amino-2'-hydroxy-1,1'-binaphthyl[J].Chinese Journal of Organic Chemistry,2008,28(2):288-292. |
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| Authors: | JIANG Yi ZHANG Xiao-Xia WANG Chao ZHANG Guo-Lin LI Bo-Gang |
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| Institution: | ( Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041)(Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041)(Graduate School of the Chinese Academy of Sciences, Beijing 100039) |
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| Abstract: | The direct aldol reactions catalyzed by organocatalyst derived from 2-amino-2'-hydroxy-1,1'- binaphthyl were studied. Up to 99% yield was obtained for acetone. Up to 99∶1 anti∶syn selectivity and 89% enantioselectivity were obtained for cycloalkanones. |
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| Keywords: | 2-amino-2'-hydroxy-1 1'-binaphthyl organocatalyst direct adol reaction |
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