不对称环丙烷化反应

利用手性类卡宾分子对烯烃的加成,可合成非对称取代的环丙烷环。其不对称诱导一般受立体和电子因素控制。本文主要综述 Simmons-Smith 反应,重氮化合物,异丙叉三苯基膦,以及一些金属有机化合物的催化热解反应在不对称环丙烷环合成中的应用,并以潜在杀虫剂环丙烷甲酸化合物的合成为例进行了讨论。

Asymmetric Cyclopropanation

Dissymmetrically substituted cyclopropane rings can be synthesized viathe addition reaction of chiral carbenoid molecules to prochiral olefins.Asymmetric in-ductions usually governed by both steric and electronic effects.This paper diseusses indetail the Simmons-Smith reaction as well as catalyzed thermal decomposition of diazo-compounds,isopropylidene triphenyl phosphine and some organometallic compounds.These methods will be examplified by the syntheses of cyclopropane carboxylic acids,which are potential insecticides.