| β-内酰胺类抗生素酶促合成新进展 |
| |
| 引用本文： | 吴伟波,王旭,王娜,吴起,林贤福.β-内酰胺类抗生素酶促合成新进展[J].有机化学,2006,26(3):292-298. |
| |
| 作者姓名： | 吴伟波 王旭 王娜 吴起 林贤福 |
| |
| 作者单位： | 1. 浙江大学化学系,杭州,310027
2. 浙江工业大学化工与材料学院,杭州,310032 |
| |
| 摘 要： | β-内酰胺类抗生素的合成在制药工业中占据重要的地位, 相关的酶促合成方法研究备受关注; 酶促合成显著提高合成效率, 减少三废的排放, 是实现绿色合成的有效方法. 综述了近年来β-内酰胺类抗生素酶促合成研究的新进展, 包括一锅合成法、原位产物排出法、介质技术和酶固定化方法.
|
| 关 键 词： | β-内酰胺类抗生素 青霉素 头孢菌素 酶促合成 绿色工艺 |
| 收稿时间： | 01 27 2005 12:00AM |
| 修稿时间： | 08 11 2005 12:00AM |
New Progress in Enzymatic Semi-Synthesis of β-Lactam Antibiotics |
| |
| WU,Wei-Bo,WANG,Xu,WANG,Na,WU,Qi,LIN,Xian-Fu.New Progress in Enzymatic Semi-Synthesis of β-Lactam Antibiotics[J].Chinese Journal of Organic Chemistry,2006,26(3):292-298. |
| |
| Authors: | WU Wei-Bo WANG Xu WANG Na WU Qi LIN Xian-Fu |
| |
| Institution: | a Department of Chemistry, Zhefiang University, Hangzhou 310027; b Instttute of Chemical Engineering and Material Science, Zhejiang University of Technology, Hangzhou 310032 |
| |
| Abstract: | Semi-synthetic β-lactam antibiotics plays a significant role in pharmaceutical industry. Enzymatic synthesis of β-lactam antibiotics provides an effective green technology, which could decline the generation of waste and the cost of production remarkably. This review focuses on the recent progresses of enzymatic semi-synthesis of β-lactam antibiotics, mainly including one-pot synthesis, in situ product removal, media techniques and immobilization techniques of enzyme. |
| |
| Keywords: | β-lactam antibiotics penicillin cephalosporin enzymatic synthesis green technology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
| 点击此处可从《有机化学》下载免费的PDF全文 |
|
