| 2-{5-[(1H-1,2,4-三唑-1-基)甲基]-4-苯基-4H-1,2,4-三唑-3-硫基}-1-芳基乙酮类化合物的合成、表征及生物活性测试 |
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| 引用本文： | 胡志强,杨亚迅,张功胜,李凯,许良忠.2-{5-[(1H-1,2,4-三唑-1-基)甲基]-4-苯基-4H-1,2,4-三唑-3-硫基}-1-芳基乙酮类化合物的合成、表征及生物活性测试[J].有机化学,2007,27(3):419-423. |
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| 作者姓名： | 胡志强 杨亚迅 张功胜 李凯 许良忠 |
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| 作者单位： | 青岛科技大学化学与分子工程学院,青岛,266042 |
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| 摘 要： | 通过α-卤代芳基乙酮和5-(1H-1,2,4-三唑-1-基)甲基]-4-苯基-2H-1,2,4-三唑-3(4H)-硫酮反应, 合成了11个新的2-{5-(1H-1,2,4-三唑-1-基)甲基]-4-苯基-4H-1,2,4-三唑-3-硫基}-1-芳基乙酮类化合物. 其结构经元素分析, IR, 1H NMR等确证, 并用X射线单晶衍射测定了化合物6f的晶体结构. 生物活性测试结果表明, 部分化合物具有一定的杀菌活性.
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| 关 键 词： | 三唑 合成 生物活性 晶体结构 |
| 收稿时间： | 2006-3-7 |
| 修稿时间： | 2006-03-06 |
Synthesis, Structure and Biological Activity of 2-{5-[(1H-1,2,4-triazol-1- yl)methyl]-4-phenyl-4H-1,2,4-triazol-3-ylthio}-1-arylethanone |
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| HU Zhi-Qiang,YANG Ya-Xun,ZHANG Gong-Sheng,LI Kai,XU Liang-Zhong.Synthesis, Structure and Biological Activity of 2-{5-[(1H-1,2,4-triazol-1- yl)methyl]-4-phenyl-4H-1,2,4-triazol-3-ylthio}-1-arylethanone[J].Chinese Journal of Organic Chemistry,2007,27(3):419-423. |
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| Authors: | HU Zhi-Qiang YANG Ya-Xun ZHANG Gong-Sheng LI Kai XU Liang-Zhong |
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| Institution: | College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042 |
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| Abstract: | Eleven novel 2-{5-(1H-1,2,4-triazol-1-yl)methyl]-4-phenyl-4H-1,2,4-triazol-3-ylthio}-1-ary-lethanone were synthesized through the reaction of α-haloacetophenone with 1,5-dihydro-4H-phenyl-3- (1,2,4-triazol-1-ylmethyl)-1,2,4-triazole-5-thione. Their structures were clearly established by elemental analysis, IR and 1H NMR spectra. The crystal structure of compound 6f has been determined by X-ray diffraction analysis. The preliminary bioassays indicated that some compounds showed certain fungicidal activities. |
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| Keywords: | triazole synthesis biological activity crystal structure |
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