| α-酮酯和α-酮酰胺的Henry反应 |
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| 引用本文： | 王亚军,沈宗旋,张雅文.α-酮酯和α-酮酰胺的Henry反应[J].有机化学,2006,26(9):1291-1294. |
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| 作者姓名： | 王亚军 沈宗旋 张雅文 |
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| 作者单位： | 苏州大学化学化工学院,江苏省有机合成重点实验室,苏州,215006 |
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| 基金项目： | 江苏省有机合成重点实验室开放课题(No.JSK015)资助项目. |
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| 摘 要： | 用三乙胺催化环状α-酮酯和α-酮酰胺同硝基甲烷的Henry反应, 首次合成了12个多官能团的β-硝基醇, 它们的结构用元素分析、红外光谱和核磁共振进行了表征. 这一反应速度较快, 室温下进行, 条件温和, 产率较好, 是合成多官能团硝基醇的有效方法.
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| 关 键 词： | Henry反应 三乙胺 α-酮酯 α-酮酰胺 β-硝基醇 |
| 收稿时间： | 10 17 2005 12:00AM |
| 修稿时间： | 03 17 2006 12:00AM |
Henry Reaction of α-Ketoesters and α-Ketoamides |
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| WANG Ya-Jun,SHEN Zong-Xuan,ZHANG Ya-Wen.Henry Reaction of α-Ketoesters and α-Ketoamides[J].Chinese Journal of Organic Chemistry,2006,26(9):1291-1294. |
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| Authors: | WANG Ya-Jun SHEN Zong-Xuan ZHANG Ya-Wen |
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| Institution: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering Suzhou University, Suzhou 215006 |
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| Abstract: | The Henry reaction of cyclic α-ketoesters and α-ketoamides was achieved using triethylamine as a promoter. Twelve new multi-functional β-nitroalcohols were synthesized. Their structures were confirmed by elemental analyses, IR, 1H NMR or 13C NMR spectroscopy. β-Nitroalcohols were produced in high yields under mild reaction conditions. |
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| Keywords: | Henry reaction triethylamine α-ketoester α-ketoamide β-nitroalcohol |
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