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核苷羧酸酯类化合物的酶法合成及其应用
引用本文:李晓凤,宗敏华,吴晖,吴虹.核苷羧酸酯类化合物的酶法合成及其应用[J].有机化学,2007,27(3):368-376.
作者姓名:李晓凤  宗敏华  吴晖  吴虹
作者单位:华南理工大学轻工与食品学院,广州,510640
基金项目:国家自然科学基金(No.20676043)、广东省自然科学基金(No.05006571)及华南理工大学自然科学基金(No.002-E5051020)资助项目.
摘    要:核苷羧酸酯是一类在有机合成、核苷化学以及医药等领域具有重要应用价值的化合物. 近年来, 该类化合物的酶法合成以其绿色、高效、高选择性等优点而成为新的研究热点. 综述了近年来该领域的研究进展.

关 键 词:核苷羧酸酯  酶促酰化  区域选择性
收稿时间:2005-12-8
修稿时间:2005-12-08

Enzymatic Synthesis and Applications of Nucleoside Carboxylates
LI Xiao-Feng,ZONG Min-Hua,WU Hui,WU Hong.Enzymatic Synthesis and Applications of Nucleoside Carboxylates[J].Chinese Journal of Organic Chemistry,2007,27(3):368-376.
Authors:LI Xiao-Feng  ZONG Min-Hua  WU Hui  WU Hong
Institution:College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640
Abstract:Nucleoside carboxylates are a group of compounds which have been found important applica- tions in nucleoside chemistry, organic synthesis and medicinal chemistry. Recently, their enzymatic synthe- sis has attracted much attention due to the high efficiency, high regioselectivity and environmental friendli- ness of enzymatic processes. The advances achieved in this area in recent years are reviewed in this paper.
Keywords:nucleoside carboxylate  enzymatic acylation  regioselectivity
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