| 含噁二唑杂环取代的新型三唑并嘧啶衍生物的合成及其生物活性 |
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| 引用本文： | 陈悟,陈琼,吴琼友,杨光富.含噁二唑杂环取代的新型三唑并嘧啶衍生物的合成及其生物活性[J].有机化学,2005,25(11):1477-1481. |
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| 作者姓名： | 陈悟 陈琼 吴琼友 杨光富 |
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| 作者单位： | 1. 华中科技大学生命科学与技术学院,武汉,430074
2. 华中师范大学化学学院,农药与化学生物学教育部重点实验室,武汉,430079 |
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| 摘 要： | 2-肼羰基亚甲硫基-5,7-二甲基-1,2,4-三唑并1,5-a]嘧啶与二硫化碳在乙醇溶液中回流制得化合物2-(5-巯基-1,3,4-噁二唑-2-亚甲硫基)-5,7-二甲基-1,2,4-三唑并1,5-a]嘧啶, 后者在碱性环境中与卤化苄反应得到17种新型双杂环化合物. 对所得化合物结构均经元素分析, 1H NMR和MS确认. 初步生物活性测试表明这些化合物具有一定的杀菌活性.
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| 关 键 词： | 三唑并嘧啶 1 3 4-噁二唑 生物活性 |
| 收稿时间： | 11 4 2004 12:00AM |
| 修稿时间： | 05 28 2005 12:00AM |
Synthesis and Fungicidal Evaluation of Novel 1,2,4-Triazolo[1,5-a]- pyrimidine Containing Oxadiazolyl De-rivatives |
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| CHEN,Wu,CHEN Qiong,WU Qiong-You,YANG,Guang-Fu.Synthesis and Fungicidal Evaluation of Novel 1,2,4-Triazolo[1,5-a]- pyrimidine Containing Oxadiazolyl De-rivatives[J].Chinese Journal of Organic Chemistry,2005,25(11):1477-1481. |
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| Authors: | CHEN Wu CHEN Qiong WU Qiong-You YANG Guang-Fu |
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| Institution: | ( College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074)(Key Laboratory of Pesticide & Chemical Biology, Ministry of Educa-tion, College of Chemistry, Central China Normal University, Wuhan 430079) |
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| Abstract: | Reaction of 2-hydrazinocarbonylmethenethio-5,7-dimethyl-1,2,4-triazolo1,5-a]pyrimidine with carbon disulfide in refluxing ethanol afforded 2-(5-mercapto-1,3,4-oxadiazol-2-ylmethylthio)-5,7-di- methyl-1,2,4-triazolo1,5-a]pyrimidine, which was then treated with various benzyl halide in basic condition to yield 17 novel biheterocyclic derivatives. The structures of all compounds obtained were confirmed by elemental analyses, 1H NMR and MS. Preliminary bioassay indicates that some compounds display anti- bacterial activity to certain extent. |
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| Keywords: | 1 2 4-triazolo[1 5-a]pyrimidine 1 3 4-oxadiazole bioactivity |
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