| 环肽的合成研究进展 |
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| 引用本文： | 王德心,韩香,龚喜,冯鹤鹤.环肽的合成研究进展[J].有机化学,2008,28(4):549-573. |
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| 作者姓名： | 王德心 韩香 龚喜 冯鹤鹤 |
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| 作者单位： | 中国医学科学院中国协和医科大学药物研究所,北京,100050 |
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| 摘 要： | 对环肽进行了分类, 并对具代表性的经典型、DKP (Diketopiperazine, 哌嗪二酮)型、醚桥型、烯桥型、单硫及多硫醚型、刚性桥型、仲(叔)胺型、Mannich碱型、联苯型及Freidinger型环肽的合成方法逐一进行了描述.
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| 关 键 词： | 环肽分类 肽结构改造 环肽合成 |
| 收稿时间： | 2007-1-27 |
| 修稿时间： | 2007年1月27日 |
Progress in Synthesis of Cyclopeptides |
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| WANG De-Xin,HAN Xiang,GONG Xi,FENG He-He.Progress in Synthesis of Cyclopeptides[J].Chinese Journal of Organic Chemistry,2008,28(4):549-573. |
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| Authors: | WANG De-Xin HAN Xiang GONG Xi FENG He-He |
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| Institution: | (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050) |
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| Abstract: | Cyclopeptide classifications have been performed systematically in present review, where the synthetic methodologies of the most representative cyclopeptides in documents, such as classical cyclopeptides and atypical cyclopeptides like DKPs (diketopiperazines), Freidingers and some loop chains containing ether, alkene, single or poly sulphur ether, rigid bridge, amine, Mannich base, biphenyl, etc., were described respectively. |
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| Keywords: | cyclopeptide classification structure modification of peptide cyclopeptide synthesis |
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