| 新型咖啡酸五环三萜酯的合成与保肝活性 |
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| 引用本文： | 贾炯,孙学华,邵腾飞,金树根,高月求,王建武.新型咖啡酸五环三萜酯的合成与保肝活性[J].有机化学,2012(4):760-764. |
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| 作者姓名： | 贾炯 孙学华 邵腾飞 金树根 高月求 王建武 |
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| 作者单位： | 1. 山东大学化学与化工学院 济南250100
2. 上海中医药大学附属曙光医院 上海201210 |
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| 摘 要： | 以天然的咖啡酸、甘草次酸和齐墩果酸为原料,采用侧基保护、还原、酰化与去保护等步骤,将咖啡酰基及氢化咖啡酰基引入到甘草次酸和齐墩果酸的3-位羟基上,以较高收率合成了4个新的咖啡酸及氢化咖啡酸五环三萜酯类化合物,通过IR,1H NMR,HRMS等方法确定了化合物的结构.
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| 关 键 词： | caffeyl glycyrrhetinate caffeyl oleanolic ester synthesis hepatic protection |
Synthesis of Novel Caffeyl Triterpenic Esters and Their Hepatic Protective Effect |
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| Jia, Jiong
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Sun, Xuehua
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Shao, Tengfei
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Jin, Shugen
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Gao, Yueqiu
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Wang, Jianwu.Synthesis of Novel Caffeyl Triterpenic Esters and Their Hepatic Protective Effect[J].Chinese Journal of Organic Chemistry,2012(4):760-764. |
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| Authors: | Jia Jiong Sun Xuehua Shao Tengfei Jin Shugen Gao Yueqiu Wang Jianwu |
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| Institution: | Jia,Jiong,a Sun,Xuehua b Shao,Tengfei a Jin,Shugen b Gao,Yueqiu b Wang,Jianwu a(a School of Chemistry and Chemical Engineering,Shandong University,Jinan 250100)(b Shanghai Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201210) |
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| Abstract: | Four new caffeyl triterpenic esters were synthesized from natural caffeic acid,glycyrrhetinic acid and oleanolic acid.The structures of all products were characterized by IR,1 H NMR and HRMS techniques.The activities of the compounds to protect liver was tested and compound 9c showed good hepatic protective effect. |
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| Keywords: | caffeyl glycyrrhetinate caffeyl oleanolic ester synthesis hepatic protection |
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