| 1-芳甲酰基-3-[4-((2-氰基亚胺基-1,3-噻唑烷-3-基)甲基)-噻唑-2-基]硫脲的合成及其生物活性研究 |
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| 引用本文： | 戴红,苗文科,刘建兵,吴珊珊,秦雪,张欣,方建新.1-芳甲酰基-3-[4-((2-氰基亚胺基-1,3-噻唑烷-3-基)甲基)-噻唑-2-基]硫脲的合成及其生物活性研究[J].有机化学,2012,32(7):1327-1331. |
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| 作者姓名： | 戴红 苗文科 刘建兵 吴珊珊 秦雪 张欣 方建新 |
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| 作者单位： | 1. 南开大学元素有机化学国家重点实验室 天津300071;南通大学化学化工学院 南通226019
2. 南开大学元素有机化学国家重点实验室 天津300071 |
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| 基金项目： | 国家自然科学基金，南通市科技计划 |
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| 摘 要： | 为了寻找高活性的杂环农药,将酰基硫脲骨架引入到噻唑分子结构中,设计合成了14个未见文献报道的1-取代苯甲酰基-3-4-((2-氰基亚胺基-1,3-噻唑烷-3-基)甲基)-噻唑-2-基]硫脲类化合物.采用核磁共振氢谱和元素分析确认了新化合物的结构.初步的生物活性测试结果表明,部分标题化合物显示出一定的杀菌、植物生长调节或除草活性.
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| 关 键 词： | 噻唑 酰基硫脲 合成 生物活性 |
Synthesis and Biological Activity of 1-Aroyl-3-[4-(( 2-cyanoim ino- 1,3-thiazolidine-3-yl)methyl)-thiazol-2-yl]thioureas |
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| Dai,Hong
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Miao,Wenke
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Liu,Jianbing
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Wu,Shanshan
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Qin,Xue
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Zhang,Xin
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Fang,Jianxin.Synthesis and Biological Activity of 1-Aroyl-3-[4-(( 2-cyanoim ino- 1,3-thiazolidine-3-yl)methyl)-thiazol-2-yl]thioureas[J].Chinese Journal of Organic Chemistry,2012,32(7):1327-1331. |
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| Authors: | Dai Hong Miao Wenke Liu Jianbing Wu Shanshan Qin Xue Zhang Xin Fang Jianxin |
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| Institution: | Dai,Hong,a,b Miao,Wenkea Liu,Jianbinga Wu,Shanshana Qin,Xuea Zhang,Xina Fang,Jianxin,a(aState Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071)(bCollege of Chemistry and Chemical Engineering,Nantong University,Nantong 226019) |
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| Abstract: | In order to explore potent pesticide containing heterocycle,fourteen new 1-aroyl-3-4-((2-cyanoimino-1,3-thiazolidine-3-yl)methyl)-thiazol-2-yl]thiourea compounds were designed and synthesized by introducing the important acylthiourea moiety into the molecular structure of thiazole.Their structures were identified by 1H NMR spectra and elemental analysis.The preliminary bioassay revealed that some compounds showed certain fungicidal,plant growth regulatory or herbicidal activities. |
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| Keywords: | thiazole acylthiourea synthesis biological activity |
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