| 微波辐射促进选择性合成4,6-二芳基-3,4-二氢嘧啶-2(1H)-酮和嘧啶-2(1H)-酮 |
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| 引用本文： | 安琳,张玲,郑友广,薛运生,牟杰,刘玲,刘毅.微波辐射促进选择性合成4,6-二芳基-3,4-二氢嘧啶-2(1H)-酮和嘧啶-2(1H)-酮[J].有机化学,2012,32(6):1108-1111. |
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| 作者姓名： | 安琳 张玲 郑友广 薛运生 牟杰 刘玲 刘毅 |
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| 作者单位： | 徐州医学院药学院 徐州221004 |
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| 基金项目： | 江苏省高校自然科学基金，州医学院药学院院长基金，江苏高校优势学科建设工程、徐州市科技计划 |
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| 摘 要： | 探讨了在微波加热条件下,芳香醛、取代苯乙酮和尿素的三组分反应在N,N-二甲基甲酰胺(DMF)中制得4,6-二芳基-3,4-二氢嘧啶-2(1H)-酮类化合物,收率为68%～84%.若在反应体系中加入三甲基氯硅烷,该三组分反应则高产率(66%～87%)地生成相应的脱氢产物4,6-二芳基嘧啶-2(1H)-酮类化合物.该反应具有反应条件温和、产物收率高、操作方便等优点,为4,6-二芳基-嘧啶-2(1H)-酮类药物中间体的合成提供了一条全新的路线.
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| 关 键 词： | 嘧啶酮 3 4-二氢嘧啶-2(1H)-酮 微波合成 多组分反应 Biginelli反应 |
Microwave Irradiation Assisted Selective Synthesis of 4,6-Diaryl-3,4-dihydropyrimidin-2(1H)-ones and Pyrimidin-2(1H)-ones |
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| An,Lin
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Zhang,Ling
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Zheng,Youguang
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Xue,Yunsheng
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Mou,Jie
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Liu,Ling
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Liu,Yi.Microwave Irradiation Assisted Selective Synthesis of 4,6-Diaryl-3,4-dihydropyrimidin-2(1H)-ones and Pyrimidin-2(1H)-ones[J].Chinese Journal of Organic Chemistry,2012,32(6):1108-1111. |
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| Authors: | An Lin Zhang Ling Zheng Youguang Xue Yunsheng Mou Jie Liu Ling Liu Yi |
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| Institution: | An,Lin Zhang,Ling Zheng,Youguang Xue,Yunsheng Mou,Jie Liu,Ling Liu,Yi(School of Pharmacy,Xuzhou Medical College,Xuzhou 221004) |
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| Abstract: | Under microwave irradiation,the three-component reaction of aromatic aldehydes,substituted acetophenones and urea in N,N-dimethyl formamide(DMF) resulted in 4,6-diaryl-3,4-dihydro-pyrimidin-2(1H)-ones in 68%～84% yields.In the presence of chlorotrimethylsilane,the three-component reactions gave the corresponding dehydrogenated 4,6-diaryl-pyrimidin-2(1H)-ones in satisfactory yields(66%～87%).This method of microwave irradiation for the preparation of 4,6-diaryl pyrimidin-2(1H)-ones was simple,efficient and reaction time-saving. |
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| Keywords: | pyrimidinone 3 4-dihydropyrimidinone microwave synthesis multicomponent reaction Biginelli reaction |
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