| 4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征 |
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| 引用本文： | 李鹏飞,王宝雷,马宁,王素华,李正名.4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征[J].有机化学,2005,25(9):1057-1061. |
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| 作者姓名： | 李鹏飞 王宝雷 马宁 王素华 李正名 |
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| 作者单位： | 南开大学元素有机化学研究所,元素有机化学国家重点实验室,天津,300071 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，天津市科委科研项目 |
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| 摘 要： | 以取代的苯磺酰肼与(取代嘧啶-2-基)-氨基甲酸苯酯在非亲核性碱存在下合成了12个4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物5和3个5与碱形成的有机盐5as, 5bs和5cs. 所有合成化合物均经过元素分析和1H NMR的结构确证. 1H NMR数据证明, 在5as～5cs中, 磺酰氨基脲起到提供质子的作用.
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| 关 键 词： | 磺酰氨基脲 合成 有机盐 |
| 收稿时间： | 2004-8-16 |
| 修稿时间： | 2004年8月16日 |
Synthesis and Characterization of New 4-(Substituted pyrimidin-2-yl)- 1-(substituted benzenesulfonyl)semicarbazides |
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| LI,Peng-Fei,WANG,Bao-Lei,MA,Ning,WANG,Su-Hua,LI,Zheng-Ming.Synthesis and Characterization of New 4-(Substituted pyrimidin-2-yl)- 1-(substituted benzenesulfonyl)semicarbazides[J].Chinese Journal of Organic Chemistry,2005,25(9):1057-1061. |
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| Authors: | LI Peng-Fei WANG Bao-Lei MA Ning WANG Su-Hua LI Zheng-Ming |
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| Institution: | (State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, |
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| Abstract: | Nucleophilic reaction of phenyl (substituted pyrimidin-2-yl)-carbamate with benzenesulfonyl hydrazine in the presence of DBU or DABCO afforded the title compounds 4-(substituted pyrimidin-2-yl)-1- (substituted benzenesulfonyl)semicarbazides 5. Three organic salts 5as～5cs formed from 5 and DBU or DABCO were also obtained. Structures of 5 and their salts were determined by elemental analysis and 1H NMR spectra. The characteristic chemical shifts of 1H NMR of such salts were discussed. |
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| Keywords: | sulfonyl semicarbazide synthesis organic salt |
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