| 2,5-二取代基-1,3,4-噁二唑及噁二唑啉类化合物的合成 |
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| 引用本文： | 刘方明,于建新,王玮,刘罡,刘育亭,陈耀祖.2,5-二取代基-1,3,4-噁二唑及噁二唑啉类化合物的合成[J].有机化学,1999(3). |
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| 作者姓名： | 刘方明 于建新 王玮 刘罡 刘育亭 陈耀祖 |
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| 作者单位： | 新疆大学化学系 乌鲁木齐830046
(刘方明，于建新，王玮，刘罡，刘育亭)，浙江大学化学系 杭州300027(陈耀祖) |
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| 基金项目： | 国家自然科学基金，新疆大学自然科学基金 |
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| 摘 要： | 2-苯基-1,2,3-连三唑-4-甲酰肼(1)与芳酸在POCl_3催化下得到6种新的2-芳基-5-(2’-苯基-1’,2’,3’-连三唑-4’-基)-1,3,4-噁二唑(2)。1与羰基化合物缩合得到相应的酰腙(3),在Ac_2O作用下环化成2-取代基-3-乙酰基-5-(2’-苯基-1’,2’,3’-连三唑-4’-基)-1,3,4-噁二唑啉(4)。化合物的结构经元素分析,IR,~1H NMR和MS确证。
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| 关 键 词： | 2-苯基-1 2 3-连三唑 1 3 4-噁二唑 1 3 4-噁二唑啉 |
Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles and Oxadiazolines |
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| LIU Fang - Ming,YU Jian - Xin,WANG Wei,LIU Gang,LIU Yu - Ting.Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles and Oxadiazolines[J].Chinese Journal of Organic Chemistry,1999(3). |
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| Authors: | LIU Fang - Ming YU Jian - Xin WANG Wei LIU Gang LIU Yu - Ting |
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| Abstract: | By the condensation of 2 - Phenyl - 1,2,3- triazole - 4 - formyl hydrazide (1) with substituted benzoic acids in the presence of phosphorus oxychloride,six novel 2 - Aryl - 5 - (2' - Phenyl - 1' ,2' ,3' - triazole -4' -yl) - 1,3,4- oxadiazoles (2) were obtained. Reaction of acid hydrazide (1) with keto compounds gives corresponding hydrazones (3),which could be readily converted to their congener oxadiazolines (4) in good yields by treatment with Ac2O. Their structures were established by elemental analysis, IR,1H NMR and MS spectroscopy. |
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| Keywords: | 2 - phenyl -1 2 3- triazole 1 3 4- Oxadiazole 1 3 4- Oxadiazoline |
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