| 3-巯基-5-芳香基-4-芳基亚甲胺基-4H-1,2,4-三唑的合成及波谱研究 |
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| 引用本文： | 张安将,张力学,丁金昌.3-巯基-5-芳香基-4-芳基亚甲胺基-4H-1,2,4-三唑的合成及波谱研究[J].有机化学,2005,25(4):442-444. |
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| 作者姓名： | 张安将 张力学 丁金昌 |
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| 作者单位： | 温州师范学院药物研究所,温州,325027 |
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| 基金项目： | 教育部高校骨干教师资助计划 |
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| 摘 要： | 5-取代-4-氨基-3-巯基-1,2,4-三唑与芳香醛在弱酸性乙醇溶液中反应, 合成了一系列3-巯基-5-芳香基-4-芳基亚甲胺基-4H-1,2,4-三唑(3a～3d)及水溶性的3-巯基-5-(D-葡萄糖-1-基)-4-(4-氯代苯基)亚甲胺基-4H-1,2,4-三唑(3e)新化合物. 以元素分析, IR, NMR, MS实验技术对其结构进行了表征, 并研究其NMR波谱特征.
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| 关 键 词： | 3-巯基-5-芳香基-4-芳基亚甲胺基-4H-1 2 4-三唑 3-巯基-5-(D-葡萄糖-1-基)-4-(4-氯代苯基)亚甲胺基-4H-1 2 4-三唑 合成 NMR |
| 收稿时间： | 2004-2-27 |
| 修稿时间： | 2004年2月27日 |
Synthesis and NMR Study of 4-(Arylmethylidene)-amino-5-aryl-3- mercapto-4H-1,2,4-triazoles |
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| ZHANG An-Jiang,ZHANG Li-Xue,DING Jin-Chang.Synthesis and NMR Study of 4-(Arylmethylidene)-amino-5-aryl-3- mercapto-4H-1,2,4-triazoles[J].Chinese Journal of Organic Chemistry,2005,25(4):442-444. |
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| Authors: | ZHANG An-Jiang ZHANG Li-Xue DING Jin-Chang |
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| Institution: | (Institute of Pharmacy, Wenzhou Normal College, Wenzhou 325027) |
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| Abstract: | 4-(Arylmethylidene)amino-5-aryl-3-mercapto-4H-1,2,4-triazoles (3a～3d) and 4-(4-chloroph- enyl-methylidene)amino-5-(D-gluco-pentitol-1-yl)-3-mercapto-4H-1,2,4-triazole (3e) were synthesized in good yields by reaction of 4-amino-3-mercapto-5-substituent-1,2,4-triazole with aryl aldehyde in ethanolic medium. Their structures were confirmed by elemental analysis, IR, NMR, MS spectra and the characteristics of NMR spectra were also discussed. |
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| Keywords: | NMR |
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