| 肽束的超分子化学 |
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| 引用本文： | 杨念祖.肽束的超分子化学[J].有机化学,1993,13(3):322-325. |
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| 作者姓名： | 杨念祖 |
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| 作者单位： | 芝加哥大学化学系 |
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| 摘 要： | 在疏水相中合成了含8-9个亮氨酸的两性十八肽,并见到自集合形成α-螺旋六聚体,这类肽的分子络合物和提取物的核磁共振谱表明这些六聚体是以扭曲的螺旋束存在,并在它的中间含有一个环状空间.
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| 关 键 词： | 亮氨酸 多肽 分子络合物 螺旋构象 超分子化学 |
Supramolecular chemistry of peptide bundles |
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| Abstract: | Amphiphilic octadecapeptides H-Glu-Gln-Leu-Leu-Lys-Ala-Leu-Glu-X-Leu-Leu-Lys-Glu-Leu-Leu-Glu-Ly s-Leu-OH (X = Phe, Trp) and H-Tyr-Leu-Leu-Glu-Lys-Leu-Leu-Lys-Leu-Leu-Glu-Glu-Leu-Leu-Lys-Gln- Leu-OH, containing 8-9 leucines in the hydrophobic phase, were prepared and shown to self-assoc. to form a-helical bundles. The NMR of the mol. complexes of the peptides and quaternary probe 4-Me(CH2)7OC6H4OCH2CH2NMe3+ I- showed that these hexamers exist as a twisted helix bundle containing and annular space in its middle. |
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| Keywords: | LEUCINE POLYPEPTIDE SUPERMOLECULAR CHEMISTRY |
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