| 双氢埃托啡的^1H, ^1^3C NMR和立体化学 |
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| 引用本文： | 缪振春,宋运金,魏同太.双氢埃托啡的^1H, ^1^3C NMR和立体化学[J].有机化学,1989,9(4):347-352. |
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| 作者姓名： | 缪振春 宋运金 魏同太 |
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| 作者单位： | 军事医学科学院毒物药物研究所 北京(缪振春，宋运金)，军事医学科学院仪器测试中心 北京(魏同太) |
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| 摘 要： | 双氢埃托啡(1)为合成的高效镇痛剂。药理实验结果表示,其镇痛作用优于吗啡。该化合物的~1H和~(13)C NMR谱都较为复杂,尚未见报道,并且多数谱峰采用一般方法难以指定。
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| 关 键 词： | 双氢埃托啡 NMR 二维NMR 立体化学 |
H, ~(13)C NMR and Stereochemistry of the Analgesic Dihydroetophine |
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| Miao Zhen-Chun,SONG YUN-JIN Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,BeijingWEI Tong-Tai,Instrumental Analysis Center,Academy of Military Medical Sciences,Beijing.H, ~(13)C NMR and Stereochemistry of the Analgesic Dihydroetophine[J].Chinese Journal of Organic Chemistry,1989,9(4):347-352. |
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| Authors: | Miao Zhen-Chun SONG YUN-JIN Institute of Pharmacology and Toxicology Academy of Military Medical Sciences BeijingWEI Tong-Tai Instrumental Analysis Center Academy of Military Medical Sciences Beijing |
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| Abstract: | The ~1H and ~(13)C NMR signals of the analgesic dihydroetophine (1) were assigned by ~1H-~1H COSY-NOESY, ~(13)C-~1H COSY and lons range ~(13)C-~1H COSY techniques. According to the 2 D NOE experiment, the C-7 and C-19 configuration of the compound have been elucidated as (2). The result was confirmed by X-ray diffraction analysis. |
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| Keywords: | dihydroetophine ~1H and ~(13)C NMR two-dimentional NMR stereochemistry |
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